Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8492378

    GSK-3β inhibitor

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8492397

    Aminopyridine derivatives having Aurora A selective inhibitory action

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8492405

    Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8497258

    Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract

    The Regents of the University of California · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8497249

    Fungicidal properties of three saponins from Capsicum frutescens

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8496938

    Anti-CD100 neutralizing neutralizing antibodies and methods of using the same

    VACCINEX, INC. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8497274

    Heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8497290

    Thiocolchicine derivatives, method of making and methods of use thereof

    Takeda Pharmaceuticals U.S.A., Inc. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8497381

    Antagonists of prostaglandin D2 receptors

    Panmira Pharmaceuticals, LLC · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8497357

    Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom

    Nektar Therapeutics · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8497295

    Spiroindoline modulators of muscarinic receptors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8496957

    Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders

    The Regents of the University of California · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8497279

    Treatment for discoid lupus

    Rigel Pharmaceuticals, Inc. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8497393

    Process to prepare treprostinil, the active ingredient in Remodulin®

    United Therapeutics Corporation · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8497307

    Aryl guanidine F1F0-ATPase inhibitors and related methods

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8497287

    Aminotetralin compounds as mu opioid receptor antagonists

    Theravance, Inc. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8497241

    WNT10-derived peptide and use thereof

    CAREGEN CO., LTD. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8497271

    Modulators of G protein-coupled receptor 88

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8497301

    Hydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Jul 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. EP 2620148

    Antitumorkombination mit Cabazitaxel und Cisplatin

    AVENTIS PHARMA SA [FR] · Granted Wed Jul 31 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jul 26 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. MX 2013007491

    GRANULATES COMPRISING ESLICARBAZEPINE ACETATE.

    BIAL PORTELA & CA SA [PT] · Granted Thu Aug 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jul 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8501404

    Gnaq mutations in melanoma

    The Regents of the University of California · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8501446

    Azaindoles useful as inhibitors of JAK and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8501686

    Method of treating fatty liver diseases and conditions in non-lipodystrophic subjects

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8501776

    Biphenyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8501798

    Dual-acting antihypertensive agents

    Theravance, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8501920

    Nucleic acid sequences encoding peptides with utrophin spectrin-like repeats

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8501926

    Malaria vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8501953

    PKM2 modulators for use in the treatment of cancer

    Agios Pharmaceuticals, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8501964

    Serotonin reuptake inhibitors

    Theravance, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. BR PI0714667

    conjugado molecular e respectivo uso

    CERAMOPTEC IND INC [US] · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8501247

    Pest control using natural pest control agent blends

    TYRATECH, INC. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8501804

    Bicyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8501722

    Methods and compositions for treating bacterial infection

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8501188

    Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8501191

    FGFR2-IIIb fusion proteins and methods of making them

    Five Prime Therapeutics, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8501229

    Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings

    ATRIUM MEDICAL CORPORATION · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8501194

    Vaccine for viruses that cause persistent or latent infections

    The Regents of the University of California · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8501423

    Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays

    The Board of Regents of the University of Texas System · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8501678

    Variant activin receptor polypeptides and uses thereof

    Atara Biotherapeutics, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8501466

    Vector

    The Pirbright Institute · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8501681

    Macrocyclic hepatitis C virus serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8501682

    Difluorinated tripeptides as HCV serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8501692

    Compositions and methods for altering cocaine esterase activity

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8501705

    Methods and materials for treating autoimmune and/or complement mediated diseases and conditions

    The Board of Regents of the University of Texas System · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8501695

    Tissue kallikrein for the treatment of diseases associated with amyloid protein

    DiaMedica Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8501688

    SCGB3A2 as a growth factor and anti-apoptotic agent

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8501704

    Immunosuppression compound and treatment method

    Sarepta Therapeutics, Inc. · Granted Tue Aug 06 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 01 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.