Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8476236

    Treatment of skin conditions by Dickkopf1 (DKK1)

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8476281

    Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8476338

    Dental curable composition and composite resin using the same

    KURARAY NORITAKE DENTAL INC. · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8476413

    Sulfanyl-tetrahydropyran-based compounds and methods of their use

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8474529

    Control of concentric tubing direction

    Regency Technologies LLC · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8476263

    Prodrugs of 2,4-pyrimidinediamine compounds and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8476043

    Inhibitors for the soluble epoxide hydrolase

    The Regents of the University of California · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8475828

    Medical apparatus and method for producing same

    Covidien LP · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8476229

    Blood sugar-modulating polypeptides

    China Medical University · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8475792

    Molecules with extended half-lives, compositions and uses thereof

    Board of Regents, The Texas University System · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8475764

    Labelled adrenomedullin derivatives and their use for imaging and therapy

    INSTITUT DE CARDIOLOGIE DE MONTREAL · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8476451

    Tubulysin D analogues

    The Regents of the University of California · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8476442

    Process for making modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 02 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. MX 2013000877

    APPLICATION OF β-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT.

    BIOLITEC PHARMA MARKETING LTD [MY] · Granted Wed Jul 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jun 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8481731

    Compounds, pharmaceutical composition and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8481578

    Thiophene-carboxamides useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8481760

    Inhibition and treatment of prostate cancer metastasis

    Northwestern University · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8481289

    Triple acting antimicrobials that are refractory to resistance development

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8481044

    Neprilysin inhibitors

    Theravance, Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8481035

    Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A

    Northwestern University · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8481024

    Vaccines against tularemia

    The Regents of the University of California · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8480995

    Use of sodium selenosulfate for supplementing selenium and enhancing the therapeutic efficacy of chemotherapy agents, and a rapid process for preparing sodium selenosulfate

    UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8481551

    Gyrase and topoisomerase IV inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8481005

    Methods to prevent cytotoxicity using N-acetyl-cysteine

    The Regents of the University of California · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8481569

    Iminopyridine derivatives and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8481757

    Compounds and compositions useful in the treatment of malaria

    The Regents of the University of California · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8481524

    c-MET protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8481313

    Retinal pigment epithelial stem cells

    REGENERATIVE RESEARCH FOUNDATION · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8481521

    Methods of treating cell proliferative disorders

    Rigel Pharmaceuticals, Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8480637

    Nanochanneled device and related methods

    The Board of Regents of the University of Texas System · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8481006

    Melt formula

    New Sunshine, LLC · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8481010

    Covalently bonding nail primer

    Creative Nail Design Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8481038

    Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins

    Five Prime Therapeutics, Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8481046

    VEGF antagonist formulations for intravitreal administration

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8481048

    Methods for preparing immunogenic conjugates

    The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8481095

    Method for anti-oxidation, inhibiting activity and/or expression of matrix metalloproteinase, and/or inhibiting phosporylation of mitogen-activated protein kinase using flemingia macrophylla extract

    China Medical University · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8481255

    Scytovirin domain 1 related polypeptides

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8481055

    Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8481311

    Progenitor cells from wharton's jelly of human umbilical cord

    Tissue Regeneration Therapeutics Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8481483

    Cyclosporin analogues

    Enanta Pharmaceuticals, Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8481511

    Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process

    Hainan Hdeton Science and Technology Co., Ltd. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8481516

    Ciclesonide containing sterile aqueous suspension

    TAKEDA GMBH · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8481478

    Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

    The Regents of the University of California · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8481507

    Micro-RNAs that control myosin expression and myofiber identity

    The Board of Regents of the University of Texas System · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8481552

    Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8481529

    Combination cancer chemotherapy

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8481538

    Heterocyclic inhibitors of c-Met and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8481549

    Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents

    Theravance, Inc. · Granted Tue Jul 09 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.