Wednesday, July 8, 2026

Drug profile · INN

vandetanib

vandetanib (ZACTIMA) is a ephrin receptor inhibitor. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Antineoplastic and immunomodulating agents (L01) L01XE
US status approved
Patents linked 0
Pipeline programs 4
News articles 0
Drug details — vandetanib
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
ORAL
Patents
0
Programs
4
Data quality
0.84

Quick answer

vandetanib (ZACTIMA) is a ephrin receptor inhibitor. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN vandetanib
Brand ZACTIMA
Mechanism Ephrin receptor inhibitor
Target Ephrin receptor
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route ORAL
Formulation TABLET
ATC code L01XE

Mechanism of action

Ephrin receptor inhibitor

Primary target: Ephrin receptor

Approval history

Authority Status Date
FDA approved
EMA approved

Pipeline programs

  1. J2G-MC-JZJB Phase 3 · Eli Lilly and · RET-Mutant Medullary Thyroid Cancer
  2. Vandetanib Phase 3 · Sanofi Pasteur MSD · Locally Advanced or Metastatic Medullary Thyroid Cancer
  3. Vandetanib Phase 3 · Sanofi Pasteur MSD · Non Small Cell Lung Cancer
  4. ZD6474 (vandetanib) Phase 3 · Sanofi Pasteur MSD · Non-Small-Cell Lung Carcinoma

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is vandetanib?

vandetanib (ZACTIMA) is a ephrin receptor inhibitor. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for vandetanib?

ZACTIMA is a marketed brand name for vandetanib. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of vandetanib?

vandetanib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.