Friday, July 10, 2026

Drug profile · INN

tretinoin

tretinoin (TRETINOIN) is a retinoic acid receptor agonist. Associated with Amneal Pharma Europe Ltd. Route of administration: topical. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 4
Pipeline programs 32
News articles 0
Drug details — tretinoin
US status
approved
Class
Route
TOPICAL
Patents
4
Programs
32
Data quality
0.89

Quick answer

tretinoin (TRETINOIN) is a retinoic acid receptor agonist. Associated with Amneal Pharma Europe Ltd. Route of administration: topical. Current US regulatory status: approved.

Key facts

INN tretinoin
Brand TRETINOIN
Mechanism Retinoic acid receptor agonist
Target Retinoic acid receptor
Route TOPICAL
Formulation CAPSULE

Mechanism of action

Retinoic acid receptor agonist

Primary target: Retinoic acid receptor

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. 23-01/ClindaTret-G Phase 3 · Alphapharm · Papulopustular acne
  2. ALN-TTR02-011 Phase 3 · Alnylam Netherlands · Transthyretin Amyloidosis with Cardiomyopathy (ATTR Amyloido
  3. ALN-TTRSC02-002 Phase 3 · Alnylam Netherlands · Hereditary Transthyretin Amyloidosis
  4. ALN-TTRSC02-003 Phase 3 · Alnylam Netherlands · Transthyretin Amyloidosis with Cardiomyopathy (ATTR Amyloido
  5. ALXN2060 Phase 3 · BridgeBio Oncology Therapeutics · Symptomatic Transthyretin Amyloid Cardiomyopathy
  6. ALXN2220-ATTRCM-301 Phase 3 · Alexion Europe SAS · Adults with Transthyretin Amyloid Cardiomyopathy (ATTR-CM).
  7. Amvuttra 25 mg solution for injection in pre-filled syringe Phase 3 · Alnylam Netherlands · Transthyretin Amyloidosis with Cardiomyopathy (ATTR Amyloido
  8. Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment Phase 3 · United Therapeutics Europe · COVID19

Related & competitor drugs

  1. isotretinoin Retinoic acid receptor agonist
  2. tazarotene Retinoic acid receptor agonist
  3. adapalene Retinoic acid receptor agonist
  4. palovarotene Musculo-skeletal system (M09)
  5. trifarotene Retinoic acid receptor gamma agonist
  1. US 12005123

    Conjugate of isotretinoin and peptide

    Expires Mon Jun 06 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11351266

    Conjugate of isotretinoin and peptide

    Expires Mon Jun 02 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 9982259

    Transthyretin allele selective UNA oligomers for gene silencing

    Expires Mon May 24 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 6080386

    Suspended ultra-sound induced microbubble cavitation imaging

    Expires Mon Jun 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired

Frequently asked questions

What is tretinoin?

tretinoin (TRETINOIN) is a retinoic acid receptor agonist. Associated with Amneal Pharma Europe Ltd. Route of administration: topical. Current US regulatory status: approved.

What is the brand name for tretinoin?

TRETINOIN is a marketed brand name for tretinoin. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of tretinoin?

tretinoin has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.