Friday, July 10, 2026

Drug profile · INN

trastuzumab emtansine

trastuzumab emtansine (KADCYLA) is a tubulin inhibitor. Associated with Hoffmann-La Roche.

EMA: approved TGA: approved PMDA: approved Antineoplastic and immunomodulating agents (L01) L01FD03
Patents linked 0
Pipeline programs 15
News articles 0
Drug details — trastuzumab emtansine
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
0
Programs
15
Data quality
0.83

Quick answer

trastuzumab emtansine (KADCYLA) is a tubulin inhibitor. Associated with Hoffmann-La Roche.

Key facts

INN trastuzumab emtansine
Brand KADCYLA
Mechanism Tubulin inhibitor
Target Receptor tyrosine-protein kinase erbB-2
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01FD03

Mechanism of action

Tubulin inhibitor

Primary target: Receptor tyrosine-protein kinase erbB-2

Approval history

Authority Status Date
EMA approved
TGA approved
PMDA approved

Pipeline programs

  1. DS8201-A-U302 Phase 3 · Daiichi Sankyo US · Metastatic breast cancer
  2. DS8201-A-U305 Phase 3 · Daiichi Sankyo US · High-Risk HER2-Positive Breast Cancer
  3. FM-17-B01 Phase 3 · Telethon Foundation · Invasive Breast Cancer
  4. HCB-ONC002 Phase 3 · George Institute for · HER2-positive early breast cancer
  5. MO43110 Phase 3 · HOFFMANN-LA ROCHE · Early or Locally Advanced/ Inflammatory HER2-Positive Breast
  6. Trastuzumab Emtansine Phase 3 · HOFFMANN-LA ROCHE · Metastatic Breast Cancer
  7. Trastuzumab emtansine Phase 3 · HOFFMANN-LA ROCHE · Breast Cancer
  8. WO42633 Phase 3 · HOFFMANN-LA ROCHE · Early human epidermal growth factor receptor 2 (HER2) positi

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is trastuzumab emtansine?

trastuzumab emtansine (KADCYLA) is a tubulin inhibitor. Associated with Hoffmann-La Roche.

What is the brand name for trastuzumab emtansine?

KADCYLA is a marketed brand name for trastuzumab emtansine. Check FDA Drugs@FDA for the current US label holder and prescribing information.