Wednesday, July 8, 2026

Drug profile · INN

trastuzumab

trastuzumab (HERZUMA) is a receptor protein-tyrosine kinase erbb-2 inhibitor. Associated with Pfizer Australia Pty Ltd. Route of administration: intravenous. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01FD01
US status approved
Patents linked 4
Pipeline programs 71
News articles 4
Drug details — trastuzumab

Quick answer

trastuzumab (HERZUMA) is a receptor protein-tyrosine kinase erbb-2 inhibitor. Associated with Pfizer Australia Pty Ltd. Route of administration: intravenous. Current US regulatory status: approved.

Key facts

INN trastuzumab
Brand HERZUMA
Mechanism Receptor protein-tyrosine kinase erbB-2 inhibitor
Target Receptor tyrosine-protein kinase erbB-2
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route INTRAVENOUS
Formulation VIAL
ATC code L01FD01

Mechanism of action

Receptor protein-tyrosine kinase erbB-2 inhibitor

Primary target: Receptor tyrosine-protein kinase erbB-2

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved
NMPA clinical trials

Recent coverage

Pipeline programs

  1. ALPELISIB for PIK3CA mutated HER2+ advanced o… Phase 3 · Ningbo Cancer Hospital · PIK3CA mutated HER2+ advanced or relapsed breast cancer (BC)
  2. AT148006 Phase 3 · Createrna Science and · Patients with HER2-overexpressing advanced or metastatic gas
  3. CTRIAL‐IE-22‐01 Phase 3 · Ningbo Cancer Hospital · Early stage HER2-positive breast cancer
  4. D702AC00001 Phase 3 · AstraZeneca · HER2-positive locally advanced or metastatic gastric or gast
  5. D967UC00001 Phase 3 · AstraZeneca · HER2-positive metastatic breast cancer
  6. HCB-ONC002 Phase 3 · George Institute for · HER2-positive early breast cancer
  7. Herceptin Phase 3 · HOFFMANN-LA ROCHE · Breast Neoplasms
  8. IFOM-CPT0092022PO008 Phase 3 · Telethon Foundation · Colon cancer

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)
  1. US 12240846

    5- and 6-azaindole compounds for inhibition of Bcr-Abl tyrosine kinases

    Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11807638

    5- and 6-azaindole compounds for inhibition of Bcr-Abl tyrosine kinases

    Expires Mon Nov 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11767321

    5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases

    Expires Mon Sep 21 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10370349

    Functionalised benzopyran compounds and use thereof

    Expires Mon Aug 01 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is trastuzumab?

trastuzumab (HERZUMA) is a receptor protein-tyrosine kinase erbb-2 inhibitor. Associated with Pfizer Australia Pty Ltd. Route of administration: intravenous. Current US regulatory status: approved.

What is the brand name for trastuzumab?

HERZUMA is a marketed brand name for trastuzumab. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of trastuzumab?

trastuzumab has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.