Wednesday, July 8, 2026

Drug profile · INN

tolcapone

tolcapone (TASMAR) is a catechol o-methyltransferase inhibitor. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Nervous system (N04) N04BX01
US status approved
Patents linked 0
Pipeline programs 3
News articles 0
Drug details — tolcapone
US status
approved
Class
Nervous system (N04)
Route
ORAL
Patents
0
Programs
3
Data quality
0.84

Quick answer

tolcapone (TASMAR) is a catechol o-methyltransferase inhibitor. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN tolcapone
Brand TASMAR
Mechanism Catechol O-methyltransferase inhibitor
Target Catechol O-methyltransferase
Therapeutic class Nervous system (N04)
Route ORAL
Formulation TABLET
ATC code N04BX01

Mechanism of action

Catechol O-methyltransferase inhibitor

Primary target: Catechol O-methyltransferase

Approval history

Authority Status Date
FDA approved
EMA approved

Pipeline programs

  1. Tolcapone Phase 2 · BRIGHT MINDS BIOSCIENCES · Tobacco Use Disorder
  2. Tolcapone Unknown · United Therapeutics Europe · Impulsive Behavior
  3. Tolcapone Unknown · BRIGHT MINDS BIOSCIENCES · Nicotine Dependence

Related & competitor drugs

  1. aripiprazole Nervous system (N05)
  2. brexpiprazole Nervous system (N05)
  3. brivaracetam Nervous system (N03)
  4. bupivacaine Nervous system (N01)
  5. buprenorphine Nervous system (N07)
  6. caffeine citrate Nervous system (N06)

Frequently asked questions

What is tolcapone?

tolcapone (TASMAR) is a catechol o-methyltransferase inhibitor. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for tolcapone?

TASMAR is a marketed brand name for tolcapone. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of tolcapone?

tolcapone has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.