Friday, July 10, 2026

Drug profile · INN

tepotinib

tepotinib (TEPMETKO) is a hepatocyte growth factor receptor inhibitor. Associated with Merck KGaA, Darmstadt, Germany.

EMA: approved TGA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01EX21
Patents linked 0
Pipeline programs 4
News articles 0
Drug details — tepotinib
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
0
Programs
4
Data quality
0.83

Quick answer

tepotinib (TEPMETKO) is a hepatocyte growth factor receptor inhibitor. Associated with Merck KGaA, Darmstadt, Germany.

Key facts

INN tepotinib
Brand TEPMETKO
Mechanism Hepatocyte growth factor receptor inhibitor
Target Hepatocyte growth factor receptor
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01EX21

Mechanism of action

Hepatocyte growth factor receptor inhibitor

Primary target: Hepatocyte growth factor receptor

Approval history

Authority Status Date
EMA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. MS200095-0031 Phase 2 · MSD Merck Sharp · Lung Cancer
  2. Tepotinib Phase 2 · Serana Europe · Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC)
  3. Tepotinib Phase 2 · MSD Merck Sharp · Lung Cancer
  4. Tepotinib Phase 1 · United Therapeutics Europe · Advanced Cancer

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is tepotinib?

tepotinib (TEPMETKO) is a hepatocyte growth factor receptor inhibitor. Associated with Merck KGaA, Darmstadt, Germany.

What is the brand name for tepotinib?

TEPMETKO is a marketed brand name for tepotinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.