Wednesday, July 8, 2026

Drug profile · INN

sodium zirconium cyclosilicate

sodium zirconium cyclosilicate (LOKELMA) is a potassium chelating agent. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Various (V03) V03AE10
US status approved
Patents linked 0
Pipeline programs 5
News articles 0
Drug details — sodium zirconium cyclosilicate
US status
approved
Class
Various (V03)
Route
ORAL
Patents
0
Programs
5
Data quality
0.84

Quick answer

sodium zirconium cyclosilicate (LOKELMA) is a potassium chelating agent. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN sodium zirconium cyclosilicate
Brand LOKELMA
Mechanism Potassium chelating agent
Target Potassium
Therapeutic class Various (V03)
Route ORAL
Formulation POWDER, FOR SUSPENSION
ATC code V03AE10

Mechanism of action

Potassium chelating agent

Primary target: Potassium

Approval history

Authority Status Date
FDA approved
EMA approved

Pipeline programs

  1. D9481C00001 Phase 3 · AstraZeneca · Hyperkalaemia
  2. KEEP-ON Phase 3 · George Institute for · Hyperkalemia in patients with chronic kidney disease
  3. Sodium Zirconium Cyclosilicate (SZC) Phase 3 · AstraZeneca · Hyperkalemia
  4. Zirconium Zr 89 Girentuximab Phase 2 · Telix Innovations · Clear Cell Renal Cell Carcinoma
  5. Sodium Zirconium Cyclosilicate (ZS) Phase 1 · AstraZeneca · Hyperkalemia

Related & competitor drugs

  1. amifampridine phosphate Voltage-gated potassium channel blocker
  2. amiodarone hydrochloride HERG blocker
  3. besilesomab Various (V09)
  4. chlorzoxazone Intermediate conductance calcium-activated potassium channel protein 4 opener
  5. dalfampridine Voltage-gated potassium channel blocker
  6. deferasirox Various (V03)

Frequently asked questions

What is sodium zirconium cyclosilicate?

sodium zirconium cyclosilicate (LOKELMA) is a potassium chelating agent. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for sodium zirconium cyclosilicate?

LOKELMA is a marketed brand name for sodium zirconium cyclosilicate. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of sodium zirconium cyclosilicate?

sodium zirconium cyclosilicate has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.