Wednesday, July 8, 2026

Drug profile · INN

selpercatinib

selpercatinib (RETEVMO) is a tyrosine-protein kinase receptor ret inhibitor. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01EX22
US status approved
Patents linked 0
Pipeline programs 9
News articles 0
Drug details — selpercatinib
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
ORAL
Patents
0
Programs
9
Data quality
0.84

Quick answer

selpercatinib (RETEVMO) is a tyrosine-protein kinase receptor ret inhibitor. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN selpercatinib
Brand RETEVMO
Mechanism Tyrosine-protein kinase receptor RET inhibitor
Target Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route ORAL
Formulation CAPSULE
ATC code L01EX22

Mechanism of action

Tyrosine-protein kinase receptor RET inhibitor

Primary target: Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. J2G-MC-JZJB Phase 3 · Eli Lilly and · RET-Mutant Medullary Thyroid Cancer
  2. J2G-MC-JZJC Phase 3 · Eli Lilly and · Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lu
  3. J2G-MC-JZJX Phase 3 · Eli Lilly and · RET fusion-Positive NSCLC
  4. Selpercatinib Phase 3 · Eli Lilly and · Non-Small Cell Lung Cancer
  5. LOXO-RET-18036 Phase 2 · Createrna Science and · Pediatric Patients with Advanced RET-Altered Solid or Primar
  6. SELPERCATINIB, SELPERCATINIB Phase 2 · Createrna Science and · Male or female patients age 12 years or older with a locally
  7. Selpercatinib Phase 2 · Eli Lilly and · Medullary Thyroid Cancer
  8. Selpercatinib Monotherapy Phase 2 · United Therapeutics Europe · Differentiated Thyroid Cancer

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is selpercatinib?

selpercatinib (RETEVMO) is a tyrosine-protein kinase receptor ret inhibitor. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for selpercatinib?

RETEVMO is a marketed brand name for selpercatinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of selpercatinib?

selpercatinib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.