Friday, July 10, 2026

Drug profile · INN

retifanlimab

retifanlimab (ZYNYZ) is a programmed cell death protein 1 antagonist.

EMA: approved Antineoplastic and immunomodulating agents (L01) L01FF10
Patents linked 0
Pipeline programs 5
News articles 0
Drug details — retifanlimab
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
0
Programs
5
Data quality
0.83

Quick answer

retifanlimab (ZYNYZ) is a programmed cell death protein 1 antagonist.

Key facts

INN retifanlimab
Brand ZYNYZ
Mechanism Programmed cell death protein 1 antagonist
Target Programmed cell death protein 1
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01FF10

Mechanism of action

Programmed cell death protein 1 antagonist

Primary target: Programmed cell death protein 1

Approval history

Authority Status Date
EMA approved

Pipeline programs

  1. Retifanlimab (INCMGA00012) for Squamous Carcinoma of the Anal Canal Phase 3 · Incyte · Squamous Carcinoma of the Anal Canal
  2. IB 2021-01 Phase 2 · George Institute for · Adult patients with treatment-naïve surgically non-metastati
  3. INCAGN 2385-203 Phase 2 · Incyte · In participants with PD-L1–positive and systemic therapy–nai
  4. INCMGA0012-204 Phase 2 · Incyte · Endometrial cancer, Endometrial cancer
  5. Retifanlimab Phase 1 · Actuate Therapeutics · Pancreatic Adenocarcinoma

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is retifanlimab?

retifanlimab (ZYNYZ) is a programmed cell death protein 1 antagonist.

What is the brand name for retifanlimab?

ZYNYZ is a marketed brand name for retifanlimab. Check FDA Drugs@FDA for the current US label holder and prescribing information.