Wednesday, July 8, 2026

Drug profile · INN

relacorilant

relacorilant (LIFYORLI (COPACKAGED)) is a glucocorticoid receptor antagonist. Associated with CORCEPT THERAPEUTICS INC. Route of administration: oral. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 20
Pipeline programs 17
News articles 1
Drug details — relacorilant

Quick answer

relacorilant (LIFYORLI (COPACKAGED)) is a glucocorticoid receptor antagonist. Associated with CORCEPT THERAPEUTICS INC. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN relacorilant
Brand LIFYORLI (COPACKAGED)
Mechanism Glucocorticoid receptor antagonist
Target Glucocorticoid receptor
Route ORAL
Formulation CAPSULE

Mechanism of action

Glucocorticoid receptor antagonist

Primary target: Glucocorticoid receptor

Approval history

Authority Status Date
FDA approved

Recent coverage

Pipeline programs

  1. CORT125134-452 Phase 3 · CORCEPT THERAPEUTICS · Endogenous Cushing Syndrome
  2. CORT125134-556 Phase 3 · CORCEPT THERAPEUTICS · Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian,
  3. Relacorilant Phase 3 · CORCEPT THERAPEUTICS · Hypercortisolism
  4. Relacorilant, 100 mg and 25 mg Phase 3 · CORCEPT THERAPEUTICS · Metastatic Pancreatic Ductal Adenocarcinoma
  5. relacorilant Phase 3 · CORCEPT THERAPEUTICS · Cushing Syndrome
  6. CORT125134-557 Phase 2 · CORCEPT THERAPEUTICS · Gynecological Cancers
  7. Relacorilant Phase 2 · CORCEPT THERAPEUTICS · Recurrent Ovarian Cancer
  8. Relacorilant 150 mg once daily (QD) Phase 2 · CORCEPT THERAPEUTICS · Adenocarcinoma

Related & competitor drugs

  1. beclomethasone dipropionate Glucocorticoid receptor agonist
  2. betamethasone acetate Glucocorticoid receptor agonist
  3. betamethasone dipropionate Glucocorticoid receptor agonist
  4. betamethasone valerate Glucocorticoid receptor agonist
  5. budesonide Alimentary tract and metabolism (A07)
  6. clobetasol propionate Glucocorticoid receptor agonist
  1. US 12336985

    Methods for shrinking pituitary tumors

    Expires Mon Jun 19 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12152028

    Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Expires Mon Nov 21 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12097192

    Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator

    Expires Mon Sep 19 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12005055

    Methods for shrinking pituitary tumors

    Expires Mon Jun 06 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11944617

    Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of CYP2C8 and CYP3A4

    Expires Mon Mar 28 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11925626

    Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound

    Expires Mon Mar 07 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11684612

    Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator

    Expires Mon Jun 22 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11590113

    Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator

    Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11576907

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11464764

    Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound

    Expires Mon Oct 06 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11285145

    Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of CYP2C8 and CYP3A4

    Expires Mon Mar 24 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11268145

    Methods for treating Cushing's syndrome

    Expires Mon Mar 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11058670

    Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator

    Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10946005

    Methods for shrinking pituitary tumors

    Expires Mon Mar 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10456392

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 9273047

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Expires Mon Feb 25 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8889867

    Solid forms and process for preparing

    Expires Mon Nov 13 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8859774

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Expires Mon Oct 09 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8598154

    Pyridyl-amine fused azadecalin modulators

    Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8461172

    Solid forms and process for preparing

    Expires Mon Jun 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is relacorilant?

relacorilant (LIFYORLI (COPACKAGED)) is a glucocorticoid receptor antagonist. Associated with CORCEPT THERAPEUTICS INC. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for relacorilant?

LIFYORLI (COPACKAGED) is a marketed brand name for relacorilant. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of relacorilant?

relacorilant has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.