Drug profile · INN
pralsetinib
GAVRETO
pralsetinib (GAVRETO) is a coiled-coil domain-containing protein 6/tyrosine-protein kinase receptor ret inhibitor. Associated with RIGEL PHARMACEUTICALS INC. Route of administration: oral. Current US regulatory status: approved.
Drug details — pralsetinib
- US status
- approved
- Class
- Antineoplastic and immunomodulating agents (L01)
- Route
- ORAL
- Patents
- 20
- Programs
- 1
- Data quality
- 0.89
Quick answer
pralsetinib (GAVRETO) is a coiled-coil domain-containing protein 6/tyrosine-protein kinase receptor ret inhibitor. Associated with RIGEL PHARMACEUTICALS INC. Route of administration: oral. Current US regulatory status: approved.
Key facts
Mechanism of action
Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitor
Primary target: Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET
Approval history
| Authority | Status | Date |
|---|---|---|
| FDA | approved | — |
| EMA | withdrawn | — |
Pipeline programs
Related & competitor drugs
Related patents
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US 11827628
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US 11667611
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granted -
US 11530194
Amide compounds and method for making and using
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granted -
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US 11198689
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US 11174251
Compositions and methods for inhibition of the JAK pathway
granted -
US 11174246
Direct AMPK activators
granted -
US 11129819
Fumarate analogs and uses thereof
granted -
US 11007193
2,4-pyrimidinediamine compounds and their uses
granted -
US 10947216
Amide compounds and method for making and using
granted -
US 10941134
AMPK-activating heterocyclic compounds and methods for using the same
granted -
US 10941135
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Frequently asked questions
What is pralsetinib?
pralsetinib (GAVRETO) is a coiled-coil domain-containing protein 6/tyrosine-protein kinase receptor ret inhibitor. Associated with RIGEL PHARMACEUTICALS INC. Route of administration: oral. Current US regulatory status: approved.
What is the brand name for pralsetinib?
GAVRETO is a marketed brand name for pralsetinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.
What is the US approval status of pralsetinib?
pralsetinib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.