Friday, July 10, 2026

Drug profile · INN

ponatinib

ponatinib (ICLUSIG) is a bcr/abl fusion protein inhibitor. Associated with Lacuna Pharma Pty Ltd.

EMA: approved TGA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01EA05
Patents linked 0
Pipeline programs 18
News articles 0
Drug details — ponatinib
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
0
Programs
18
Data quality
0.83

Quick answer

ponatinib (ICLUSIG) is a bcr/abl fusion protein inhibitor. Associated with Lacuna Pharma Pty Ltd.

Key facts

INN ponatinib
Brand ICLUSIG
Mechanism Bcr/Abl fusion protein inhibitor
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01EA05

Mechanism of action

Bcr/Abl fusion protein inhibitor

Approval history

Authority Status Date
EMA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. HQP1351AG301 Phase 3 · Anaxis Pharma · Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymph
  2. Ponatinib Phase 3 · Takeda · Philadelphia Chromosome Positive Acute Lymphoblastic Leukemi
  3. Ponatinib 30 mg QD Phase 3 · Takeda · Chronic Phase Chronic Myeloid Leukemia
  4. Ponatinib-3001 Phase 3 · Takeda · Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymph
  5. ALL2418 Phase 2 · Telethon Foundation · Acute B-cell Lymphoblastic Leukemia with minimal residual po
  6. ALL2620 Phase 2 · Telethon Foundation · Ph+ Acute Lymphoblastic Leukemia
  7. AP24534-14-203 Phase 2 · Takeda · Chronic Phase Chronic Myeloid Leukemia
  8. INCB 84344-102 Phase 2 · Incyte · Recurrent or Refractory Leukemias, Lymphomas, and Solid Tumo

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is ponatinib?

ponatinib (ICLUSIG) is a bcr/abl fusion protein inhibitor. Associated with Lacuna Pharma Pty Ltd.

What is the brand name for ponatinib?

ICLUSIG is a marketed brand name for ponatinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.