Wednesday, July 8, 2026

Drug profile · INN

pemetrexed

pemetrexed (PEMETREXED ACCORD) is a thymidylate synthase inhibitor. Associated with Lacuna Pharma Pty Ltd. Route of administration: injection. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01BA04
US status approved
Patents linked 0
Pipeline programs 24
News articles 0
Drug details — pemetrexed
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
INJECTION
Patents
0
Programs
24
Data quality
0.84

Quick answer

pemetrexed (PEMETREXED ACCORD) is a thymidylate synthase inhibitor. Associated with Lacuna Pharma Pty Ltd. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN pemetrexed
Brand PEMETREXED ACCORD
Mechanism Thymidylate synthase inhibitor
Target Dihydrofolate reductase
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route INJECTION
Formulation INJECTABLE
ATC code L01BA04

Mechanism of action

Thymidylate synthase inhibitor

Primary target: Dihydrofolate reductase

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. 22615 Phase 3 · Bayer · Advanced non-small cell lung cancer with HER2 (ERBB2) mutati
  2. CO45042 Phase 3 · HOFFMANN-LA ROCHE · Previously Untreated Advanced or Metastatic Non-Squamous Non
  3. CSET N° 2023/3729 Phase 3 · George Institute for · Synchronous oligometastatic non-small cell lung cancer (NSCL
  4. CT-P51 3.1 Phase 3 · Celltrion Healthcare Australia · Previously Untreated Metastatic Non-Squamous Non-Small Cell
  5. D5087C00001 Phase 3 · AstraZeneca · Non-Small Cell Lung Cancer
  6. D798AC00001 Phase 3 · AstraZeneca · Metastatic Non-Small Cell Lung Cancer (mNSCLC)
  7. DIDaC/ NVALT35 Phase 3 · Disc Medicine · Patients with advanced, metastatic NSCLC that have not progr
  8. INCMGA 0012-304 Phase 3 · Incyte · Metastatic nonsquamous or squamous non-small cell lung cance

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. aminosalicylate sodium Dihydrofolate reductase inhibitor
  3. anagrelide Antineoplastic and immunomodulating agents (L01)
  4. apremilast Antineoplastic and immunomodulating agents (L04)
  5. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  6. axitinib Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is pemetrexed?

pemetrexed (PEMETREXED ACCORD) is a thymidylate synthase inhibitor. Associated with Lacuna Pharma Pty Ltd. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for pemetrexed?

PEMETREXED ACCORD is a marketed brand name for pemetrexed. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of pemetrexed?

pemetrexed has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.