Friday, July 10, 2026

Drug profile · INN

olezarsen

olezarsen (TRYNGOLZA) is a apolipoprotein c-iii mrna antisense inhibitor.

EMA: approved Cardiovascular system (C10) C10AX
Patents linked 0
Pipeline programs 5
News articles 0
Drug details — olezarsen
Class
Cardiovascular system (C10)
Route
Patents
0
Programs
5
Data quality
0.83

Quick answer

olezarsen (TRYNGOLZA) is a apolipoprotein c-iii mrna antisense inhibitor.

Key facts

INN olezarsen
Brand TRYNGOLZA
Mechanism Apolipoprotein C-III mRNA antisense inhibitor
Target Apolipoprotein C-III mRNA
Therapeutic class Cardiovascular system (C10)
ATC code C10AX

Mechanism of action

Apolipoprotein C-III mRNA antisense inhibitor

Primary target: Apolipoprotein C-III mRNA

Approval history

Authority Status Date
EMA approved

Pipeline programs

  1. Olezarsen Phase 3 · IONIS PHARMACEUTICALS · Severe Hypertriglyceridemia
  2. Olezarsen Phase 3 · IONIS PHARMACEUTICALS · Familial Chylomicronemia Syndrome
  3. Olezarsen Phase 3 · IONIS PHARMACEUTICALS · Hypertriglyceridemia
  4. APOC-III-L-Rx Phase 1 · IONIS PHARMACEUTICALS · Elevated Triglycerides (TG)
  5. Olezarsen Phase 1 · IONIS PHARMACEUTICALS · Healthy Participants

Related & competitor drugs

  1. alirocumab Cardiovascular system (C10)
  2. aliskiren Cardiovascular system (C09)
  3. azilsartan medoxomil Cardiovascular system (C09)
  4. bempedoic acid Cardiovascular system (C10)
  5. bosentan Cardiovascular system (C02)
  6. dofetilide Cardiovascular system (C01)

Frequently asked questions

What is olezarsen?

olezarsen (TRYNGOLZA) is a apolipoprotein c-iii mrna antisense inhibitor.

What is the brand name for olezarsen?

TRYNGOLZA is a marketed brand name for olezarsen. Check FDA Drugs@FDA for the current US label holder and prescribing information.