Wednesday, July 8, 2026

Drug profile · INN

olaparib

olaparib (LYNPARZA) is a parp 1, 2 and 3 inhibitor. Associated with AstraZeneca. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01XK01
US status approved
Patents linked 0
Pipeline programs 52
News articles 0
Drug details — olaparib
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
ORAL
Patents
0
Programs
52
Data quality
0.84

Quick answer

olaparib (LYNPARZA) is a parp 1, 2 and 3 inhibitor. Associated with AstraZeneca. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN olaparib
Brand LYNPARZA
Mechanism PARP 1, 2 and 3 inhibitor
Target PARP 1, 2 and 3
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route ORAL
Formulation CAPSULE
ATC code L01XK01
Originator AstraZeneca

Mechanism of action

PARP 1, 2 and 3 inhibitor

Primary target: PARP 1, 2 and 3

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved
NMPA clinical trials

Pipeline programs

  1. C16-40 Phase 3 · George Institute for · Unresectable locally advanced and/or metastatic soft-tissue
  2. CBYL719K12301 Phase 3 · Novartis India · Platinum-resistant or refractory, high-grade serous ovarian
  3. CSET 2023/3603 Phase 3 · George Institute for · Patients with a histological diagnosis of p53abn HREC, treat
  4. D0817C00098 Phase 3 · AstraZeneca · BRCA Mutated Ovarian Cancer Patients, Epithelian ovarian can
  5. D081CC00006 Phase 3 · AstraZeneca · Breast Cancer
  6. D926QC00001 Phase 3 · AstraZeneca · Triple Negative or Hormone Receptor low/HER2-negative Breast
  7. D9311C00001 Phase 3 · AstraZeneca · Endometrial Cancer
  8. DUO-O/D081RC00001 Phase 3 · AstraZeneca · Newly diagnosed advanced (FIGO stage III-IV) high grade epit

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is olaparib?

olaparib (LYNPARZA) is a parp 1, 2 and 3 inhibitor. Associated with AstraZeneca. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for olaparib?

LYNPARZA is a marketed brand name for olaparib. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of olaparib?

olaparib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.