Wednesday, July 8, 2026

Drug profile · INN

mifepristone

mifepristone (CORLUXIN) is a progesterone receptor antagonist. Associated with Teva Pharma GmbH. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: application withdrawn Nervous system (NOT) Not yet assigned
US status approved
Patents linked 20
Pipeline programs 18
News articles 3
Drug details — mifepristone

Quick answer

mifepristone (CORLUXIN) is a progesterone receptor antagonist. Associated with Teva Pharma GmbH. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN mifepristone
Brand CORLUXIN
Mechanism Progesterone receptor antagonist
Target Glucocorticoid receptor
Therapeutic class Nervous system (NOT)
Route ORAL
Formulation TABLET
ATC code Not yet assigned

Mechanism of action

Progesterone receptor antagonist

Primary target: Glucocorticoid receptor

Approval history

Authority Status Date
FDA approved
EMA application withdrawn

Recent coverage

Pipeline programs

  1. Mifepristone Phase 3 · CORCEPT THERAPEUTICS · Depressive Disorder, Major
  2. Mifepristone Phase 3 · Hospital Authority · Miscarriage
  3. mifepristone Phase 3 · CORCEPT THERAPEUTICS · Major Depressive Disorder
  4. mifepristone Phase 3 · CORCEPT THERAPEUTICS · Psychotic Depression
  5. mifepristone Phase 3 · CORCEPT THERAPEUTICS · Cushing's Syndrome
  6. mifepristone Phase 3 · CORCEPT THERAPEUTICS · Cushing's Disease
  7. Mifepristone Phase 2 · CORCEPT THERAPEUTICS · Alzheimer's Disease
  8. Mifepristone Phase 2 · CORCEPT THERAPEUTICS · Central Adrenal Insufficiency

Related & competitor drugs

  1. aripiprazole Nervous system (N05)
  2. beclomethasone dipropionate Glucocorticoid receptor agonist
  3. betamethasone acetate Glucocorticoid receptor agonist
  4. betamethasone dipropionate Glucocorticoid receptor agonist
  5. betamethasone valerate Glucocorticoid receptor agonist
  6. brexpiprazole Nervous system (N05)
  1. US 12097210

    Concomitant administration of glucocorticoid receptor modulators and CYP3A inhibitors

    Expires Mon Sep 19 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11969435

    Concomitant administration of glucocorticoid receptor modulators and CYP3A inhibitors

    Expires Mon Apr 25 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11173165

    Optimizing mifepristone levels for Cushing's patients

    Expires Mon Nov 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10842801

    Optimizing mifepristone absorption

    Expires Mon Nov 19 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10842800

    Concomitant administration of glucocorticoid receptor modulators and CYP3A inhibitors

    Expires Mon Nov 19 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10780097

    Use of cortisol in assessment and prophylactic treatment of hypokalemia associated with glucocorticoid receptor modulator treatment of Cushing's syndrome patients

    Expires Mon Sep 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10660904

    Optimizing mifepristone levels for cushing's patients

    Expires Mon May 21 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10500216

    Optimizing mifepristone absorption

    Expires Mon Dec 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10495650

    Method for differentially diagnosing ACTH-dependent Cushing's syndrome

    Expires Mon Nov 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10314850

    Use of ACTH in assessment and prophylactic treatment of hypokalemia associated with glucocorticoid receptor modulator treatment of Cushing's syndrome patients

    Expires Mon Jun 06 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10231983

    Use of ACTH in assessment and prophylactic treatment of hypokalemia associated with glucocorticoid receptor modulator treatment of Cushing's syndrome patients

    Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10195214

    Concomitant administration of glucocorticoid receptor modulators and CYP3A inhibitors

    Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10166243

    Optimizing mifepristone levels for cushing'S patients

    Expires Mon Dec 27 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10166242

    Optimizing mifepristone levels for Cushing's patients

    Expires Mon Dec 27 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10151763

    Treatment and differential diagnosis of Cushing's disease and ectopic Cushing's syndrome

    Expires Mon Dec 06 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10006924

    Method for differentially diagnosing ACTH-dependent cushing's syndrome

    Expires Mon Jun 21 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9943526

    Optimizing mifepristone levels for cushing's patients

    Expires Mon Apr 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9829495

    Method for differentially diagnosing ACTH-dependent Cushing's syndrome

    Expires Mon Nov 23 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8921348

    Optimizing mifepristone levels in plasma serum of patients suffering from mental disorders treatable with glucocorticoid receptor antagonists

    Expires Mon Dec 25 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8598149

    Optimizing mifepristone levels in plasma serum of patients suffering from mental disorders treatable with glucocorticoid receptor antagonists

    Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is mifepristone?

mifepristone (CORLUXIN) is a progesterone receptor antagonist. Associated with Teva Pharma GmbH. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for mifepristone?

CORLUXIN is a marketed brand name for mifepristone. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of mifepristone?

mifepristone has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.