Friday, July 10, 2026

Drug profile · INN

luspatercept

luspatercept (REBLOZYL) is a transforming growth factor beta inhibitor.

EMA: approved Blood and blood forming organs (B03) B03XA06
Patents linked 0
Pipeline programs 7
News articles 0
Drug details — luspatercept
Class
Blood and blood forming organs (B03)
Route
Patents
0
Programs
7
Data quality
0.83

Quick answer

luspatercept (REBLOZYL) is a transforming growth factor beta inhibitor.

Key facts

INN luspatercept
Brand REBLOZYL
Mechanism Transforming growth factor beta inhibitor
Target Transforming growth factor beta
Therapeutic class Blood and blood forming organs (B03)
ATC code B03XA06

Mechanism of action

Transforming growth factor beta inhibitor

Primary target: Transforming growth factor beta

Approval history

Authority Status Date
EMA approved

Pipeline programs

  1. ACE-536-LTFU-001 Phase 3 · Celgene · myelodysplastic syndrome (MDS); beta (β)-thalassemia (THAL);
  2. ACE-536-MF-002 Phase 3 · Celgene · Anemia associated with myeloproliferative neoplasm (MPN)-ass
  3. CA0561060 Phase 3 · Celgene · Myelodysplastic syndrome
  4. Luspatercept Phase 2 · Chinese Academy of · HSCT
  5. Luspatercept combined with low-dose thalidomide Phase 2 · First People's Hospital · Transfusion-dependent β-thalassemia Patients
  6. Reblozyl 75 mg powder for solution for injection Phase 2 · GSK Glaxo Smith · Myelofibrosis
  7. Luspatercept Unknown · First People's Hospital · Transfusion-dependent Non-severe Aplastic Anemia

Related & competitor drugs

  1. apixaban Blood and blood forming organs (B01)
  2. berotralstat Blood and blood forming organs (B06)
  3. bivalirudin Blood and blood forming organs (B01)
  4. c1 inhibitor (human) Blood and blood forming organs (B06)
  5. clopidogrel Blood and blood forming organs (B01)
  6. dabigatran etexilate Blood and blood forming organs (B01)

Frequently asked questions

What is luspatercept?

luspatercept (REBLOZYL) is a transforming growth factor beta inhibitor.

What is the brand name for luspatercept?

REBLOZYL is a marketed brand name for luspatercept. Check FDA Drugs@FDA for the current US label holder and prescribing information.