Wednesday, July 8, 2026

Drug profile · INN

loncastuximab tesirine-lpyl

loncastuximab tesirine-lpyl (ZYNLONTA) is a b-lymphocyte antigen cd19 binding agent. Associated with ADC Therapeutics SA. Route of administration: injection. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 1
Pipeline programs 13
News articles 0
Drug details — loncastuximab tesirine-lpyl
US status
approved
Class
Route
INJECTION
Patents
1
Programs
13
Data quality
0.89

Quick answer

loncastuximab tesirine-lpyl (ZYNLONTA) is a b-lymphocyte antigen cd19 binding agent. Associated with ADC Therapeutics SA. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN loncastuximab tesirine-lpyl
Brand ZYNLONTA
Mechanism B-lymphocyte antigen CD19 binding agent
Target B-lymphocyte antigen CD19
Route INJECTION
Formulation INJECTABLE

Mechanism of action

B-lymphocyte antigen CD19 binding agent

Primary target: B-lymphocyte antigen CD19

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Loncastuximab Tesirine Phase 3 · ADC Therapeutics · Relapsed Diffuse Large B-Cell Lymphoma
  2. Loncastuximab Tesirine Phase 2 · ADC Therapeutics · Relapsed or Refractory Large B-cell Lymphoma
  3. Loncastuximab Tesirine Phase 2 · ADC Therapeutics · Waldenstrom Macroglobulinemia
  4. Loncastuximab Tesirine Phase 2 · ADC Therapeutics · Diffuse Large B-cell Lymphoma
  5. Loncastuximab Tesirine Phase 2 · ADC Therapeutics · Relapsed Follicular Lymphoma
  6. Loncastuximab tesirine Phase 2 · ADC Therapeutics · Post-transplant Lymphoproliferative Disorder
  7. Loncastuximab tesirine Phase 2 · ADC Therapeutics · Diffuse Large B-Cell Lymphoma Refractory
  8. Loncastuximab tesirine Phase 2 · ADC Therapeutics · Follicular Lymphoma

Related & competitor drugs

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  3. inebilizumab-cdon B-lymphocyte antigen CD19 binding agent
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  5. axicabtagene ciloleucel Antineoplastic and immunomodulating agents (L01)
  6. brexucabtagene autoleucel Antineoplastic and immunomodulating agents (L01)
  1. US 11084872

    Method for treating breast cancer

    Expires Mon Aug 05 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is loncastuximab tesirine-lpyl?

loncastuximab tesirine-lpyl (ZYNLONTA) is a b-lymphocyte antigen cd19 binding agent. Associated with ADC Therapeutics SA. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for loncastuximab tesirine-lpyl?

ZYNLONTA is a marketed brand name for loncastuximab tesirine-lpyl. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of loncastuximab tesirine-lpyl?

loncastuximab tesirine-lpyl has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.