Friday, July 10, 2026

Drug profile · INN

larotrectinib

larotrectinib (VITRAKVI) is a neurotrophic tyrosine kinase receptor inhibitor. Associated with Bayer Australia Ltd.

EMA: approved TGA: approved Antineoplastic and immunomodulating agents (L01) L01XE53
Patents linked 0
Pipeline programs 4
News articles 1
Drug details — larotrectinib

Quick answer

larotrectinib (VITRAKVI) is a neurotrophic tyrosine kinase receptor inhibitor. Associated with Bayer Australia Ltd.

Key facts

INN larotrectinib
Brand VITRAKVI
Mechanism Neurotrophic tyrosine kinase receptor inhibitor
Target Neurotrophic tyrosine kinase receptor
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01XE53

Mechanism of action

Neurotrophic tyrosine kinase receptor inhibitor

Primary target: Neurotrophic tyrosine kinase receptor

Approval history

Authority Status Date
EMA approved
TGA approved

Recent coverage

Pipeline programs

  1. 20289 Phase 2 · Bayer · Solid tumors harboring NTRK fusion
  2. 20290 Phase 2 · Bayer · Solid tumors harboring NTRK fusion
  3. BAY2757556 (Larotrectinib, Vitrakvi) Phase 2 · Bayer HealthCare Animal · Solid Tumors Harboring NTRK Fusion
  4. Larotrectinib Phase 1 · Hospital Authority · High Grade Glioma

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is larotrectinib?

larotrectinib (VITRAKVI) is a neurotrophic tyrosine kinase receptor inhibitor. Associated with Bayer Australia Ltd.

What is the brand name for larotrectinib?

VITRAKVI is a marketed brand name for larotrectinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.