Wednesday, July 8, 2026

Drug profile · INN

ketorolac tromethamine

ketorolac tromethamine (ACULAR LS) is a cyclooxygenase inhibitor. Associated with Amphastar France Pharmaceuticals. Route of administration: nasal. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 20
Pipeline programs 118
News articles 0
Drug details — ketorolac tromethamine
US status
approved
Class
Route
NASAL
Patents
20
Programs
118
Data quality
0.89

Quick answer

ketorolac tromethamine (ACULAR LS) is a cyclooxygenase inhibitor. Associated with Amphastar France Pharmaceuticals. Route of administration: nasal. Current US regulatory status: approved.

Key facts

INN ketorolac tromethamine
Brand ACULAR LS
Mechanism Cyclooxygenase inhibitor
Target Cyclooxygenase
Route NASAL
Formulation SOLUTION

Mechanism of action

Cyclooxygenase inhibitor

Primary target: Cyclooxygenase

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. 13406 Phase 3 · Regeneron UK · Macular Degeneration
  2. 15161 Phase 3 · Bayer HealthCare Animal · Macular Edema
  3. 15161 Phase 3 · Regeneron UK · Macular Edema
  4. 2.0 mg intravitreal aflibercept Phase 3 · Regeneron UK · Diabetic Macular Edema
  5. 22153 Phase 3 · Regeneron UK · Macular Edema Secondary to Retinal Vein Occlusion
  6. 4D-150 IVT (3E10 vg/eye) Phase 3 · 4D Molecular Therapeutics · Neovascular Age-Related Macular Degeneration (nAMD)
  7. 4D-150 IVT (3E10 vg/eye) Phase 3 · 4D Molecular Therapeutics · Macular Neovascularization Secondary to Age-Related Macular
  8. 4D-150-C004 Phase 3 · 4D Molecular Therapeutics · Macular neovascularization secondary to age-related macular

Related & competitor drugs

  1. aspirin Cyclooxygenase inhibitor
  2. bromfenac sodium Cyclooxygenase inhibitor
  3. diclofenac potassium Cyclooxygenase inhibitor
  4. diclofenac sodium Cyclooxygenase inhibitor
  5. diflunisal Nervous system (N02)
  6. fenoprofen calcium Cyclooxygenase inhibitor
  1. US 12344842

    Compositions and methods for treating and preventing macular degeneration

    Expires Mon Jun 26 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12116622

    Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF

    Expires Mon Oct 10 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12097188

    Compositions and methods for the treatment of macular degeneration

    Expires Mon Sep 19 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12084515

    Compositions and methods for treatment of diabetic macular edema

    Expires Mon Sep 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11969401

    Compositions and methods for treating or limiting development of age-related macular degeneration

    Expires Mon Apr 25 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11769597

    Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF

    Expires Mon Sep 21 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11519020

    Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF

    Expires Mon Dec 01 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11046785

    Compositions and methods for treatment of diabetic macular edema

    Expires Mon Jun 24 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11040055

    Method of treating diabetic retinopathy or wet type adult macular degeneration

    Expires Mon Jun 17 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10968278

    Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same

    Expires Mon Apr 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10905770

    Topical delivery of therapeutic agents using cell-penetrating peptides for the treatment of age-related macular degeneration and other eye diseases

    Expires Mon Jan 28 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 2020339710

    GLYCOPHOSPHOLIPID POLYMERIC NETWORK AND USE THEREOF

    Expires Wed Oct 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 2020239601

    CROSSLINKED POLYMERIC NETWORK AND USE THEREOF

    Expires Wed Jul 25 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10640771

    Compositions and methods for treating and preventing macular degeneration

    Expires Mon Apr 30 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10426817

    Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics

    Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10111862

    Traps in the treatment of macular degeneration

    Expires Mon Oct 25 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10000753

    Age-related macular degeneration treatment

    Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9861600

    Methods and compositions for treating and identifying compounds to treat age-related macular degeneration treatment

    Expires Mon Jan 04 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9814701

    Compositions and methods for the treatment of macular degeneration

    Expires Mon Nov 09 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9795673

    Treating macular degeneration using antibodies to aminophospholipids

    Expires Mon Oct 19 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is ketorolac tromethamine?

ketorolac tromethamine (ACULAR LS) is a cyclooxygenase inhibitor. Associated with Amphastar France Pharmaceuticals. Route of administration: nasal. Current US regulatory status: approved.

What is the brand name for ketorolac tromethamine?

ACULAR LS is a marketed brand name for ketorolac tromethamine. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of ketorolac tromethamine?

ketorolac tromethamine has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.