Wednesday, July 8, 2026

Drug profile · INN

ipilimumab

ipilimumab (YERVOY) is a cytotoxic t-lymphocyte protein 4 inhibitor. Associated with Bristol-Myers Squibb Australia Pty Ltd. Route of administration: injection. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01FX04
US status approved
Patents linked 6
Pipeline programs 50
News articles 1
Drug details — ipilimumab
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
INJECTION
Patents
6
Programs
50
Data quality
0.84

Quick answer

ipilimumab (YERVOY) is a cytotoxic t-lymphocyte protein 4 inhibitor. Associated with Bristol-Myers Squibb Australia Pty Ltd. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN ipilimumab
Brand YERVOY
Mechanism Cytotoxic T-lymphocyte protein 4 inhibitor
Target Cytotoxic T-lymphocyte protein 4
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route INJECTION
Formulation INJECTABLE
ATC code L01FX04

Mechanism of action

Cytotoxic T-lymphocyte protein 4 inhibitor

Primary target: Cytotoxic T-lymphocyte protein 4

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved
NMPA clinical trials

Recent coverage

Pipeline programs

  1. 2023/3764 Phase 3 · George Institute for · Metastatic renal cell carcinoma (mRCC)
  2. CA209-8HW Phase 3 · Bristol-Myers Squibb Australia · Microsatellite Instability High (MSI-H) or Mismatch Repair D
  3. CA209-8Y8 Phase 3 · Bristol-Myers Squibb Australia · Advanced Renal Cell Carcinoma with Intermediate- or Poor-Ris
  4. CA209-9DW Phase 3 · Bristol-Myers Squibb Australia · Hepatocellular Carcinoma, Hepatocellular Carcinoma, Hepatoce
  5. CA209-9ER Phase 3 · Bristol-Myers Squibb Australia · Advanced or Metastatic Renal Cell Carcinoma
  6. CA209-9LA Phase 3 · Bristol-Myers Squibb Australia · Stage IV Non-Small Cell Lung Cancer (NSCLC)
  7. CSET N° 2023/3729 Phase 3 · George Institute for · Synchronous oligometastatic non-small cell lung cancer (NSCL
  8. D7988C00001 Phase 3 · AstraZeneca · Unresectable Pleural Mesothelioma

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)
  1. US 11534488

    Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability

    Expires Mon Dec 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10800853

    Use of semaphorin-4D binding molecules for treating neurodegenerative disorders

    Expires Mon Oct 08 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10385136

    Use of semaphorin-4D binding molecules for treating neurodegenerative disorders

    Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 9790271

    Methods for increasing immunoglobulin A levels

    Expires Mon Oct 12 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 9598495

    Use of semaphorin-4D binding molecules for treating neurodegenerative disorders

    Expires Mon Mar 16 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 9249227

    Use of semaphorin-4D binding molecules for treating neurodegenerative disorders

    Expires Mon Jan 28 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is ipilimumab?

ipilimumab (YERVOY) is a cytotoxic t-lymphocyte protein 4 inhibitor. Associated with Bristol-Myers Squibb Australia Pty Ltd. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for ipilimumab?

YERVOY is a marketed brand name for ipilimumab. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of ipilimumab?

ipilimumab has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.