Saturday, July 11, 2026

Drug profile · INN

hydroxycarbamide

hydroxycarbamide (HYDREA) is a ribonucleoside-diphosphate reductase rr1 inhibitor.

EMA: approved TGA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01XX05
Patents linked 0
Pipeline programs 8
News articles 0
Drug details — hydroxycarbamide
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
0
Programs
8
Data quality
0.83

Quick answer

hydroxycarbamide (HYDREA) is a ribonucleoside-diphosphate reductase rr1 inhibitor.

Key facts

INN hydroxycarbamide
Brand HYDREA
Mechanism Ribonucleoside-diphosphate reductase RR1 inhibitor
Target Ribonucleoside-diphosphate reductase RR1
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01XX05

Mechanism of action

Ribonucleoside-diphosphate reductase RR1 inhibitor

Primary target: Ribonucleoside-diphosphate reductase RR1

Approval history

Authority Status Date
EMA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. DSC/08/2357/32 Phase 3 · ITALFARMACO S.P.A · JAK2V617F-positive high-risk Polycythemia Vera
  2. FEDR-MF-002 Phase 3 · Celgene · Primary myelofibrosis, post-polycythemia vera myelofibrosis
  3. MK-3543-007 Phase 3 · MSD Merck Sharp · Essential thrombocythemia
  4. EORTC 2334-BTG Phase 2 · Ningbo Cancer Hospital · Recurrent Meningioma without local treatment options (Surger
  5. Hydroxycarbamid Phase 2 · BRIGHT MINDS BIOSCIENCES · Central Retinal Vein Occlusion, Non-Ischemic
  6. NN7533-4470 Phase 2 · NovoThirteen · Sickle cell disease
  7. SIKLOS PAEDIATRIC 50mg dispersible tablets Phase 2 · theravia · Sickle Cell Disease
  8. STP938-301 Phase 1 · Anaxis Pharma · Thrombocythaemia

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is hydroxycarbamide?

hydroxycarbamide (HYDREA) is a ribonucleoside-diphosphate reductase rr1 inhibitor.

What is the brand name for hydroxycarbamide?

HYDREA is a marketed brand name for hydroxycarbamide. Check FDA Drugs@FDA for the current US label holder and prescribing information.