Friday, July 10, 2026

Drug profile · INN

glucarpidase

glucarpidase (VORAXAZE) is a methotrexate hydrolytic enzyme. Route of administration: injection. Current US regulatory status: approved.

FDA: approved EMA: approved Various (V03) V03AF09
US status approved
Patents linked 0
Pipeline programs 1
News articles 0
Drug details — glucarpidase
US status
approved
Class
Various (V03)
Route
INJECTION
Patents
0
Programs
1
Data quality
0.84

Quick answer

glucarpidase (VORAXAZE) is a methotrexate hydrolytic enzyme. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN glucarpidase
Brand VORAXAZE
Mechanism Methotrexate hydrolytic enzyme
Target Methotrexate
Therapeutic class Various (V03)
Route INJECTION
Formulation INJECTABLE
ATC code V03AF09

Mechanism of action

Methotrexate hydrolytic enzyme

Primary target: Methotrexate

Approval history

Authority Status Date
FDA approved
EMA approved

Pipeline programs

  1. Dose dense re-challenge of high dose methotre... Phase 1 · PARItec · Oncology: RELAPSED PRIMARY CNS LYMPHOMA

Related & competitor drugs

  1. besilesomab Various (V09)
  2. deferasirox Various (V03)
  3. ferric citrate coordination complex Various (V03)
  4. folic acid Various (V04)
  5. sevelamer carbonate Various (V03)
  6. sugammadex sodium Various (V03)

Frequently asked questions

What is glucarpidase?

glucarpidase (VORAXAZE) is a methotrexate hydrolytic enzyme. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for glucarpidase?

VORAXAZE is a marketed brand name for glucarpidase. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of glucarpidase?

glucarpidase has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.