Friday, July 10, 2026

Drug profile · INN

etirinotecan pegol

etirinotecan pegol (ONZEALD) is a dna topoisomerase i inhibitor. Associated with Nektar Therapeutics UK Limited.

EMA: refused Antineoplastic and immunomodulating agents (L01) L01
Patents linked 20
Pipeline programs 2
News articles 0
Drug details — etirinotecan pegol
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
20
Programs
2
Data quality
0.89

Quick answer

etirinotecan pegol (ONZEALD) is a dna topoisomerase i inhibitor. Associated with Nektar Therapeutics UK Limited.

Key facts

INN etirinotecan pegol
Brand ONZEALD
Mechanism DNA topoisomerase I inhibitor
Target DNA topoisomerase 1
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01

Mechanism of action

DNA topoisomerase I inhibitor

Primary target: DNA topoisomerase 1

Approval history

Authority Status Date
EMA refused

Pipeline programs

  1. IRINOTECAN Phase 3 · COLLEGIUM PHARMACEUTICAL · Gastric Carcinoma
  2. Etirinotecan pegol Phase 2 · Nektar Therapeutics UK · Anaplastic Astrocytomas

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)
  1. US 12324828

    Conjugates of a factor VIII moiety having an oxime-containing linkage

    Expires 2045-06-05T00:00:00.000Z

    granted
  2. US 12247059

    Conjugates of an IL-2 moiety and a polymer

    Expires 2045-03-06T00:00:00.000Z

    granted
  3. US 12016952

    Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition

    Expires 2044-06-20T00:00:00.000Z

    granted
  4. US 11932726

    Method of making releasable polymeric reagents

    Expires 2044-03-14T00:00:00.000Z

    granted
  5. US 11834553

    Alkoxylation methods

    Expires 2043-11-30T00:00:00.000Z

    granted
  6. US 11672776

    Multi-arm polymeric alkanoate conjugates

    Expires 2043-06-08T00:00:00.000Z

    granted
  7. US 11634540

    Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method

    Expires 2043-04-20T00:00:00.000Z

    granted
  8. US 11628205

    Conjugates of a factor VIII moiety having an oxime-containing linkage

    Expires 2043-04-13T00:00:00.000Z

    granted
  9. US 11266742

    Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates

    Expires 2042-03-03T00:00:00.000Z

    granted
  10. US 11220575

    Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method

    Expires 2042-01-06T00:00:00.000Z

    granted
  11. US 11141465

    Method of making a water-soluble polymer-factor VIII moiety conjugate

    Expires 2041-10-07T00:00:00.000Z

    granted
  12. US 11111214

    Kappa opioid agonists and uses thereof

    Expires 2041-09-02T00:00:00.000Z

    granted
  13. US 11111335

    Method of preparing carboxylic acid functionalized polymers

    Expires 2041-09-02T00:00:00.000Z

    granted
  14. US 11033631

    Methods of treating CYP2D6 alternative metabolizers

    Expires 2041-06-10T00:00:00.000Z

    granted
  15. US 11007270

    Polymer-semaxanib moiety conjugates

    Expires 2041-05-13T00:00:00.000Z

    granted
  16. US 10960079

    Conjugates of an IL-2 moiety and a polymer

    Expires 2041-03-25T00:00:00.000Z

    granted
  17. US 10945972

    Particulate materials

    Expires 2041-03-11T00:00:00.000Z

    granted
  18. US 10881738

    Oligomer-beta blocker conjugates

    Expires 2040-12-31T00:00:00.000Z

    granted
  19. US 10869933

    Oligomer-phenothiazine conjugates

    Expires 2040-12-17T00:00:00.000Z

    granted
  20. US 10865186

    Opioid agonists and uses thereof

    Expires 2040-12-10T00:00:00.000Z

    granted

Frequently asked questions

What is etirinotecan pegol?

etirinotecan pegol (ONZEALD) is a dna topoisomerase i inhibitor. Associated with Nektar Therapeutics UK Limited.

What is the brand name for etirinotecan pegol?

ONZEALD is a marketed brand name for etirinotecan pegol. Check FDA Drugs@FDA for the current US label holder and prescribing information.