Wednesday, July 8, 2026

Drug profile · INN

eplerenone

eplerenone (APO-EPLERENONE) is a mineralocorticoid receptor antagonist. Associated with Alphapharm Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

FDA: approved TGA: approved
US status approved
Patents linked 0
Pipeline programs 3
News articles 0
Drug details — eplerenone
US status
approved
Class
Route
ORAL
Patents
0
Programs
3
Data quality
0.84

Quick answer

eplerenone (APO-EPLERENONE) is a mineralocorticoid receptor antagonist. Associated with Alphapharm Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN eplerenone
Brand APO-EPLERENONE
Mechanism Mineralocorticoid receptor antagonist
Target Mineralocorticoid receptor
Route ORAL
Formulation TABLET

Mechanism of action

Mineralocorticoid receptor antagonist

Primary target: Mineralocorticoid receptor

Approval history

Authority Status Date
FDA approved
TGA approved

Pipeline programs

  1. Eplerenone Phase 3 · Pfizer · Heart Failure
  2. Eplerenone Phase 3 · Pfizer · Hypertension
  3. EPLERENONE Phase 2 · George Institute for · Heart failure with reduced ejection fraction in combination

Related & competitor drugs

  1. spironolactone Cardiovascular system (C03)
  2. desoxycorticosterone acetate Mineralocorticoid receptor agonist
  3. desoxycorticosterone pivalate Mineralocorticoid receptor agonist
  4. drospirenone Progesterone receptor agonist
  5. felodipine Voltage-gated L-type calcium channel blocker
  6. finerenone Cardiovascular system (C09)

Frequently asked questions

What is eplerenone?

eplerenone (APO-EPLERENONE) is a mineralocorticoid receptor antagonist. Associated with Alphapharm Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for eplerenone?

APO-EPLERENONE is a marketed brand name for eplerenone. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of eplerenone?

eplerenone has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.