Wednesday, July 8, 2026

Drug profile · INN

enasidenib mesylate

enasidenib mesylate (IDHIFA) is a isocitrate dehydrogenase [nadp], mitochondrial inhibitor. Route of administration: oral. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 6
Pipeline programs 4
News articles 0
Drug details — enasidenib mesylate
US status
approved
Class
Route
ORAL
Patents
6
Programs
4
Data quality
0.84

Quick answer

enasidenib mesylate (IDHIFA) is a isocitrate dehydrogenase [nadp], mitochondrial inhibitor. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN enasidenib mesylate
Brand IDHIFA
Mechanism Isocitrate dehydrogenase [NADP], mitochondrial inhibitor
Target Isocitrate dehydrogenase [NADP], mitochondrial
Route ORAL
Formulation TABLET

Mechanism of action

Isocitrate dehydrogenase [NADP], mitochondrial inhibitor

Primary target: Isocitrate dehydrogenase [NADP], mitochondrial

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. AG-221-AML-005 Phase 2 · Celgene · Acute Myeloid Leukemia (AML)
  2. Enasidenib Phase 2 · Agios Netherlands · Hematologic Neoplasms
  3. Enasidenib Mesylate Phase 2 · Jazz Pharmaceuticals Ireland · Recurrent Acute Myeloid Leukemia
  4. 2020-306-GLOB1 Phase 1 · Hutchison Medi Pharma · - Acute myeloid leukemia - Myelodysplastic syndrome/ Myelopr

Related patents

  1. US 10610125

    Methods and compositions for cell-proliferation-related disorders

    Expires Mon Apr 02 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10294215

    Therapeutically active compounds and their methods of use

    Expires Mon May 16 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10093654

    Therapeutically active compounds and their methods of use

    Expires Mon Oct 04 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 9738625

    Therapeutically active compounds and their methods of use

    Expires Mon Aug 17 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 9732062

    Therapeutically active compounds and their methods of use

    Expires Mon Aug 10 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 9512107

    Therapeutically active compositions and their methods of use

    Expires Mon Dec 01 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is enasidenib mesylate?

enasidenib mesylate (IDHIFA) is a isocitrate dehydrogenase [nadp], mitochondrial inhibitor. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for enasidenib mesylate?

IDHIFA is a marketed brand name for enasidenib mesylate. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of enasidenib mesylate?

enasidenib mesylate has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.