Wednesday, July 8, 2026

Drug profile · INN

deutivacaftor

deutivacaftor (ALYFTREK) is a cystic fibrosis transmembrane conductance regulator activator. Associated with Vertex Pharmaceuticals (Australia) Pty.. Route of administration: oral. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 20
Pipeline programs 1
News articles 0
Drug details — deutivacaftor
US status
approved
Class
Route
ORAL
Patents
20
Programs
1
Data quality
0.89

Quick answer

deutivacaftor (ALYFTREK) is a cystic fibrosis transmembrane conductance regulator activator. Associated with Vertex Pharmaceuticals (Australia) Pty.. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN deutivacaftor
Brand ALYFTREK
Mechanism Cystic fibrosis transmembrane conductance regulator activator
Target Cystic fibrosis transmembrane conductance regulator
Route ORAL
Formulation TABLET

Mechanism of action

Cystic fibrosis transmembrane conductance regulator activator

Primary target: Cystic fibrosis transmembrane conductance regulator

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. VX20-121-104 Phase 3 · Vertex Pharmaceuticals (Australia) · Cystic Fibrosis

Related & competitor drugs

  1. ivacaftor Respiratory system (R07)
  2. lumacaftor Respiratory system (R07)
  3. tezacaftor Respiratory system (R07)
  1. US 12421251

    Cystic fibrosis transmembrane conductance regulator modulating agents

    Expires Mon Sep 18 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12384790

    Pteridinone compounds and uses thereof

    Expires Mon Aug 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12377252

    Implantation devices, system, and methods

    Expires Mon Jul 31 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12324802

    Modulators of cystic fibrosis transmembrane conductance regulator

    Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 12281057

    Carboxamides as modulators of sodium channels

    Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 12269831

    Modulators of cystic fibrosis transmembrane conductance regulator

    Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 12258333

    N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

    Expires Mon Mar 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 12247021

    Substituted tetrahydrofurans as modulators of sodium channels

    Expires Mon Mar 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 12194138

    Devices and methods for delivering therapeutics

    Expires Mon Jan 09 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 12186306

    Methods of treatment for cystic fibrosis

    Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 12168009

    Modulators of cystic fibrosis transmembrane conductance regulator

    Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 12031150

    Methods, compositions and kits for increasing genome editing efficiency

    Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11951212

    Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

    Expires Mon Apr 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11951206

    Cell housing device

    Expires Mon Apr 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11919887

    Substituted tetrahydrofurans as modulators of sodium channels

    Expires Mon Feb 29 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11873300

    Crystalline forms of CFTR modulators

    Expires Mon Jan 11 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11866450

    Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators

    Expires Mon Jan 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11827627

    N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

    Expires Mon Nov 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11773119

    Prodrugs of pyridone amides useful as modulators of sodium channels

    Expires Mon Sep 28 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11673864

    Pyridone amides as modulators of sodium channels

    Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is deutivacaftor?

deutivacaftor (ALYFTREK) is a cystic fibrosis transmembrane conductance regulator activator. Associated with Vertex Pharmaceuticals (Australia) Pty.. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for deutivacaftor?

ALYFTREK is a marketed brand name for deutivacaftor. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of deutivacaftor?

deutivacaftor has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.