Friday, July 10, 2026

Drug profile · INN

denosumab

denosumab (CORORA) is a tumor necrosis factor ligand superfamily member 11 inhibitor. Associated with Amgen. Route of administration: subcutaneous. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved Musculo-skeletal system (M05) M05BX04
US status approved
Patents linked 5
Pipeline programs 8
News articles 3
Drug details — denosumab

Quick answer

denosumab (CORORA) is a tumor necrosis factor ligand superfamily member 11 inhibitor. Associated with Amgen. Route of administration: subcutaneous. Current US regulatory status: approved.

Key facts

INN denosumab
Brand CORORA
Mechanism Tumor necrosis factor ligand superfamily member 11 inhibitor
Target Tumor necrosis factor ligand superfamily member 11
Therapeutic class Musculo-skeletal system (M05)
Route SUBCUTANEOUS
Formulation INJECTABLE
ATC code M05BX04
Originator Amgen

Mechanism of action

Tumor necrosis factor ligand superfamily member 11 inhibitor

Primary target: Tumor necrosis factor ligand superfamily member 11

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved

Recent coverage

Pipeline programs

  1. BRCA-P/ABCSG 50 Phase 3 · Shanghai Zerun Biotechnology · Prevention of breast cancer in women with a BRCA1 germline m
  2. Denosumab Phase 3 · Amgen · Cancer
  3. LY06006/MRCT-301 Phase 3 · Createrna Science and · Postmenopausal osteoporosis
  4. ZOSTER ICO-N-2018-14 Phase 3 · CERo Therapeutics · Patients, men or women over 18 old, with inoperable vertebra
  5. denosumab Phase 3 · GSK Glaxo Smith · Osteoporosis, Postmenopausal
  6. Denosumab Phase 2 · Chinese Academy of · Lung Cancer
  7. Pembrolizumab plus denosumab Phase 2 · Zealand Pharma · Renal Cell Carcinoma, Clear Cell
  8. Sodium Chloride Fresenius Kabi Italia 0.9 % S... Approved · Disc Medicine · Fibrous dysplasia/McCune-Albright syndrome

Related & competitor drugs

  1. allopurinol Musculo-skeletal system (M04)
  2. colchicine Musculo-skeletal system (M04)
  3. eteplirsen Musculo-skeletal system (M09)
  4. febuxostat Musculo-skeletal system (M04)
  5. ibandronic acid Musculo-skeletal system (M05)
  6. lesinurad Musculo-skeletal system (M04)
  1. US 8309071

    Foamy viral envelope genes

    Expires Mon Nov 08 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8293803

    Retinoid compounds and their use

    Expires Mon Oct 18 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 7183334

    Low temperature molding compositions with solid thermoplastic elastomer thickeners and fiber reinforcement

    Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 6433037

    Method of preparing molding compositions with fiber reinforcement and products obtained therefrom

    Expires Mon Aug 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired
  5. US 6103779

    Method of preparing molding compositions with fiber reinforcement and products obtained therefrom

    Expires Mon Aug 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired

Frequently asked questions

What is denosumab?

denosumab (CORORA) is a tumor necrosis factor ligand superfamily member 11 inhibitor. Associated with Amgen. Route of administration: subcutaneous. Current US regulatory status: approved.

What is the brand name for denosumab?

CORORA is a marketed brand name for denosumab. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of denosumab?

denosumab has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.