Friday, July 10, 2026

Drug profile · INN

cobimetinib

cobimetinib (COTELLIC) is a dual specificity mitogen-activated protein kinase kinase 2 inhibitor. Associated with Hoffmann-La Roche.

EMA: approved TGA: approved Antineoplastic and immunomodulating agents (L01) L01XE38
Patents linked 1
Pipeline programs 7
News articles 0
Drug details — cobimetinib
Class
Antineoplastic and immunomodulating agents (L01)
Route
Patents
1
Programs
7
Data quality
0.83

Quick answer

cobimetinib (COTELLIC) is a dual specificity mitogen-activated protein kinase kinase 2 inhibitor. Associated with Hoffmann-La Roche.

Key facts

INN cobimetinib
Brand COTELLIC
Mechanism Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
Target Dual specificity mitogen-activated protein kinase kinase 1
Therapeutic class Antineoplastic and immunomodulating agents (L01)
ATC code L01XE38

Mechanism of action

Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Primary target: Dual specificity mitogen-activated protein kinase kinase 1

Approval history

Authority Status Date
EMA approved
TGA approved

Pipeline programs

  1. BO40729 Phase 3 · HOFFMANN-LA ROCHE · Advanced Malignancies
  2. Cobimetinib Phase 2 · HOFFMANN-LA ROCHE · Solid Tumors
  3. Cotellic 20 mg film-coated tablets, Ginisortamab Phase 2 · Ningbo Cancer Hospital · Metastatic pancreatic ductal adenocarcinoma
  4. NEO-TIM Phase 2 · Telethon Foundation · high-risk, surgically resectable BRAF mutated and wild-type
  5. WO42178 Phase 2 · HOFFMANN-LA ROCHE · Persistent or Recurrent Rare Epithelial Ovarian Tumors
  6. Cobimetinib Phase 1 · Cardiff Oncology · Locally Advanced Pancreatic Ductal Adenocarcinoma
  7. WP43295 Phase 1 · HOFFMANN-LA ROCHE · BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRAF-V60

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)
  1. US 10407403

    Preparation method of cobimetinib

    Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is cobimetinib?

cobimetinib (COTELLIC) is a dual specificity mitogen-activated protein kinase kinase 2 inhibitor. Associated with Hoffmann-La Roche.

What is the brand name for cobimetinib?

COTELLIC is a marketed brand name for cobimetinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.