Wednesday, July 8, 2026

Drug profile · INN

carfilzomib

carfilzomib (KYPROLIS) is a 26s proteosome inhibitor. Associated with Amgen. Route of administration: injection. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved NMPA: clinical trials Antineoplastic and immunomodulating agents (L01) L01XX45
US status approved
Patents linked 0
Pipeline programs 25
News articles 0
Drug details — carfilzomib
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
INJECTION
Patents
0
Programs
25
Data quality
0.89

Quick answer

carfilzomib (KYPROLIS) is a 26s proteosome inhibitor. Associated with Amgen. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN carfilzomib
Brand KYPROLIS
Mechanism 26S proteosome inhibitor
Target 26S proteasome
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route INJECTION
Formulation POWDER
ATC code L01XX45
Originator Amgen

Mechanism of action

26S proteosome inhibitor

Primary target: 26S proteasome

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved
NMPA clinical trials

Pipeline programs

  1. 64007957MMY3006 Phase 3 · Janssen-Cilag International N.V · Relapsed/refractory multiple myeloma
  2. BB2121-MM-003 Phase 3 · Celgene · Multiple myeloma (MM) with at least 2 prior therapies includ
  3. C1071032 Phase 3 · First Biotech (Australia) · Relapsed/Refractory Multiple Myeloma
  4. CA058-1019 Phase 3 · Celgene · Relapsed and/or Refractory Multiple Myeloma
  5. CA088-1007 Phase 3 · Celgene · Relapsed or Refractory and Lenalidomide exposed Multiple Mye
  6. Carfilzomib Phase 3 · Amgen · Multiple Myeloma
  7. D8311C00001 Phase 3 · AstraZeneca · Relapsed or Refractory Multiple Myeloma
  8. EMN20 Phase 3 · Telethon Foundation · PATIENTS WITH NEW DIAGNOSIS MULTIPLE MYELOMA WITH AGE >= 65

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is carfilzomib?

carfilzomib (KYPROLIS) is a 26s proteosome inhibitor. Associated with Amgen. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for carfilzomib?

KYPROLIS is a marketed brand name for carfilzomib. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of carfilzomib?

carfilzomib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.