Wednesday, July 8, 2026

Drug profile · INN

cabozantinib

cabozantinib (CABOMETYX) is a hepatocyte growth factor receptor inhibitor. Associated with Ipsen. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved Antineoplastic and immunomodulating agents (L01) L01XE
US status approved
Patents linked 8
Pipeline programs 15
News articles 0
Drug details — cabozantinib
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
ORAL
Patents
8
Programs
15
Data quality
0.89

Quick answer

cabozantinib (CABOMETYX) is a hepatocyte growth factor receptor inhibitor. Associated with Ipsen. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN cabozantinib
Brand CABOMETYX
Mechanism Hepatocyte growth factor receptor inhibitor
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route ORAL
Formulation TABLET
ATC code L01XE
Originator Ipsen

Mechanism of action

Hepatocyte growth factor receptor inhibitor

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved

Pipeline programs

  1. Cabozantinib Phase 3 · Takeda · Metastatic Prostate Cancer
  2. J2G-MC-JZJB Phase 3 · Eli Lilly and · RET-Mutant Medullary Thyroid Cancer
  3. MK-6482-011 Phase 3 · MSD Merck Sharp · Advanced RCC with clear cell component
  4. MK-6482-033 Phase 3 · MSD Merck Sharp · Renal Cell Carcinoma
  5. PEAK-1 Phase 3 · Arcus Biosciences · Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear C
  6. CA209-8TT Phase 2 · Bristol-Myers Squibb Australia · Pan tumor
  7. CABOZANTINIB Phase 2 · Telethon Foundation · Patients with metastatic clear cell renal cell carcinoma pre
  8. Cabozantinib Phase 2 · Takeda · Advanced Renal Cell Carcinoma

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)
  1. US 12410170

    2,3,5-trisubstituted pyrazolo[1,5-A]pyrimidine compounds

    Expires Mon Sep 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12384773

    Thiazole compounds and methods of use thereof

    Expires Mon Aug 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11993584

    Solid forms of an azolopyrimidine compound

    Expires Mon May 23 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11667662

    Modulators of 5′-nucleotidase, ecto and the use thereof

    Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11478479

    Dosing with an azolopyrimidine compound

    Expires Mon Oct 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11001603

    Modulators of 5′-nucleotidase, ecto and the use thereof

    Expires Mon May 06 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10981944

    Modulators of 5′-nucleotidase, ecto and the use thereof

    Expires Mon Apr 15 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10239912

    Modulators of 5′-nucleotidase, ecto and the use thereof

    Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is cabozantinib?

cabozantinib (CABOMETYX) is a hepatocyte growth factor receptor inhibitor. Associated with Ipsen. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for cabozantinib?

CABOMETYX is a marketed brand name for cabozantinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of cabozantinib?

cabozantinib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.