Wednesday, July 8, 2026

Drug profile · INN

avapritinib

avapritinib (AYVAKYT) is a stem cell growth factor receptor inhibitor. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Antineoplastic and immunomodulating agents (L01) L01EX18
US status approved
Patents linked 0
Pipeline programs 6
News articles 0
Congress events 1
Drug details — avapritinib
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
ORAL
Patents
0
Programs
6
Data quality
0.84

Quick answer

avapritinib (AYVAKYT) is a stem cell growth factor receptor inhibitor. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN avapritinib
Brand AYVAKYT
Mechanism Stem cell growth factor receptor inhibitor
Target Platelet-derived growth factor receptor alpha
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route ORAL
Formulation TABLET
ATC code L01EX18

Mechanism of action

Stem cell growth factor receptor inhibitor

Primary target: Platelet-derived growth factor receptor alpha

Approval history

Authority Status Date
FDA approved
EMA approved

Congress & event coverage

  • Presentation
    EULAR 2026

    1 presentation · immunology

Pipeline programs

  1. avapritinib Phase 3 · Blueprint Medicines · GIST
  2. BLU-285-2203 Phase 2 · Blueprint Medicines · Indolent Systemic Mastocytosis (ISM)
  3. BLU-285-3101 Phase 2 · Blueprint Medicines · Solid Tumors Dependent on KIT or PDGFRA Signaling
  4. Group A (FIT): Avapritinib + IA regimen Phase 2 · First People's Hospital · Acute Myeloid Leukemia With T(8;21)(Q22;Q22)
  5. IIT2024097 Phase 2 · Chinese Academy of · AML (Acute Myelogenous Leukemia)
  6. Avapritinib, Avapritinib Approved · Blueprint Medicines · Systemic Mastocytosis

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is avapritinib?

avapritinib (AYVAKYT) is a stem cell growth factor receptor inhibitor. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for avapritinib?

AYVAKYT is a marketed brand name for avapritinib. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of avapritinib?

avapritinib has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.