Friday, July 10, 2026

Drug profile · INN

anifrolumab

anifrolumab (SAPHNELO) is a interferon-alpha/beta receptor alpha chain antagonist. Associated with AstraZeneca.

EMA: approved TGA: approved Antineoplastic and immunomodulating agents (L04) L04AG11
Patents linked 0
Pipeline programs 9
News articles 0
Drug details — anifrolumab
Class
Antineoplastic and immunomodulating agents (L04)
Route
Patents
0
Programs
9
Data quality
0.83

Quick answer

anifrolumab (SAPHNELO) is a interferon-alpha/beta receptor alpha chain antagonist. Associated with AstraZeneca.

Key facts

INN anifrolumab
Brand SAPHNELO
Mechanism Interferon-alpha/beta receptor alpha chain antagonist
Target Interferon alpha/beta receptor 1
Therapeutic class Antineoplastic and immunomodulating agents (L04)
ATC code L04AG11
Originator AstraZeneca

Mechanism of action

Interferon-alpha/beta receptor alpha chain antagonist

Primary target: Interferon alpha/beta receptor 1

Approval history

Authority Status Date
EMA approved
TGA approved

Pipeline programs

  1. Anifrolumab Phase 3 · AstraZeneca · Lupus Nephritis
  2. Anifrolumab Phase 3 · AstraZeneca · Moderate-to-severe Systemic Lupus Erythematosus (SLE)
  3. Anifrolumab Phase 3 · AstraZeneca · Active Systemic Lupus Erythematosus
  4. Anifrolumab Phase 3 · AstraZeneca · Cutaneous Lupus Erythematosus
  5. Anifrolumab Phase 3 · AstraZeneca · Systemic Lupus Erythematosus
  6. Anifrolumab, Anifrolumab Placebo Phase 3 · AstraZeneca · Polymyositis or dermatomyositis according to 2017 EULAR / AC
  7. D346BC00001 Phase 3 · AstraZeneca · Cutaneous Lupus Erythematosus
  8. IRIS, D3466C00001 Phase 3 · AstraZeneca · Active Proliferative Lupus Nephritis

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. anagrelide Antineoplastic and immunomodulating agents (L01)
  3. apremilast Antineoplastic and immunomodulating agents (L04)
  4. arsenic trioxide Antineoplastic and immunomodulating agents (L01)
  5. axitinib Antineoplastic and immunomodulating agents (L01)
  6. azacitidine Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is anifrolumab?

anifrolumab (SAPHNELO) is a interferon-alpha/beta receptor alpha chain antagonist. Associated with AstraZeneca.

What is the brand name for anifrolumab?

SAPHNELO is a marketed brand name for anifrolumab. Check FDA Drugs@FDA for the current US label holder and prescribing information.