Wednesday, July 8, 2026

Drug profile · INN

aflibercept

aflibercept (AFQLIR) is a placenta growth factor inhibitor. Associated with Bayer Australia Ltd. Route of administration: injection. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved Sensory organs (S01) S01LA05
US status approved
Patents linked 20
Pipeline programs 85
News articles 0
Drug details — aflibercept
US status
approved
Class
Sensory organs (S01)
Route
INJECTION
Patents
20
Programs
85
Data quality
0.89

Quick answer

aflibercept (AFQLIR) is a placenta growth factor inhibitor. Associated with Bayer Australia Ltd. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN aflibercept
Brand AFQLIR
Mechanism Placenta growth factor inhibitor
Target Placenta growth factor
Therapeutic class Sensory organs (S01)
Route INJECTION
Formulation INJECTABLE
ATC code S01LA05

Mechanism of action

Placenta growth factor inhibitor

Primary target: Placenta growth factor

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved

Pipeline programs

  1. 13406 Phase 3 · Regeneron UK · Macular Degeneration
  2. 14130 Phase 3 · Regeneron UK · Retinal Vein Occlusion
  3. 15161 Phase 3 · Bayer HealthCare Animal · Macular Edema
  4. 15161 Phase 3 · Regeneron UK · Macular Edema
  5. 2-mg Intravitreous Aflibercept Injection Phase 3 · Regeneron UK · Proliferative Diabetic Retinopathy
  6. 2.0 mg intravitreal aflibercept Phase 3 · Regeneron UK · Diabetic Macular Edema
  7. 22153 Phase 3 · Regeneron UK · Macular Edema Secondary to Retinal Vein Occlusion
  8. 4D-150-C004 Phase 3 · 4D Molecular Therapeutics · Macular neovascularization secondary to age-related macular

Related & competitor drugs

  1. atropine sulfate Sensory organs (S01)
  2. bimatoprost Sensory organs (S01)
  3. aflibercept-abzv Placenta growth factor inhibitor
  4. aflibercept-ayyh Placenta growth factor inhibitor
  5. aflibercept-jbvf Placenta growth factor inhibitor
  6. aflibercept-mrbb Placenta growth factor inhibitor
  1. WO 2025146482

    FINÉRÉNONE DESTINÉE À ÊTRE UTILISÉE DANS UN PROCÉDÉ DE PRÉVENTION OU DE TRAITEMENT D'UNE INSUFFISANCE CARDIAQUE CHEZ UN PATIENT RECEVANT UN INHIBITEUR DE CYP3A4 OU UN INDUCTEUR DE CYP3A4

    Expires Wed Jul 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. EP 4567716

    ERZEUGUNG SYNTHETISCHER DARSTELLUNGEN

    Expires Tue Jun 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. EP 4567715

    ERZEUGUNG SYNTHETISCHER DARSTELLUNGEN

    Expires Tue Jun 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12280093

    Use of a VEGF receptor-based fusion protein antagonist to treat nonproliferative diabetic retinopathy

    Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 12268730

    Use of a VEGF antagonist to treat angiogenic eye disorders

    Expires Mon Apr 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 12202883

    Anti-VEGF protein compositions and methods for producing the same

    Expires Mon Jan 16 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 12168036

    Methods for treating angiogenic eye disorders with high doses of VEGF receptor fusion proteins

    Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 12116622

    Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF

    Expires Mon Oct 10 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 12077570

    Anti-VEGF protein compositions and methods for producing the same

    Expires Mon Aug 29 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 12054533

    Anti-VEGF protein compositions and methods for producing the same

    Expires Mon Aug 01 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11986511

    Use of a VEGF antagonist to treat angiogenic eye disorders

    Expires Mon May 16 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11975045

    Use of a VEGF antagonist to treat angiogenic eye disorders

    Expires Mon May 02 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11769597

    Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF

    Expires Mon Sep 21 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11753459

    Anti-VEGF protein compositions and methods for producing the same

    Expires Mon Sep 07 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11732024

    VEGF antagonist formulations suitable for intravitreal administration

    Expires Mon Aug 17 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11732025

    Anti-VEGF protein compositions and methods for producing the same

    Expires Mon Aug 17 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11707506

    Use of a VEGF antagonist to treat angiogenic eye disorders

    Expires Mon Jul 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11667702

    Stable aqueous formulations of aflibercept

    Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11649273

    Anti-VEGF protein compositions and methods for producing the same

    Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11559564

    Use of a VEGF antagonist to treat angiogenic eye disorders

    Expires Mon Jan 19 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is aflibercept?

aflibercept (AFQLIR) is a placenta growth factor inhibitor. Associated with Bayer Australia Ltd. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for aflibercept?

AFQLIR is a marketed brand name for aflibercept. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of aflibercept?

aflibercept has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.