Wednesday, July 8, 2026

pharma · Facioscapulohumeral Muscular Dystrophy (FSHD) · Facioscapulohumeral Muscular Dystrophy 1 (FSHD1) · FULC

Fulcrum Therapeutics

Fulcrum Therapeutics is a pharma organization headquartered in Cambridge, USA. It trades on NYSE under ticker FULC. Primary therapeutic focus areas include Facioscapulohumeral Muscular Dystrophy (FSHD), Facioscapulohumer

26 Landsdowne St, Cambridge, Massachusetts 02139, US HQ
2016 Founded
73 Employees
Public company Type
FULC · NYSE Ticker
Company details

Quick answer

Fulcrum Therapeutics is a pharma organization headquartered in Cambridge, USA. It trades on NYSE under ticker FULC. Primary therapeutic focus areas include Facioscapulohumeral Muscular Dystrophy (FSHD), Facioscapulohumeral Muscular Dystrophy 1 (FSHD1), Sickle Cell Disease, Campylobacter Infection, Facioscapulohumeral Muscular Dystrophy 1. NovaPharmaNews links 12 clinical program(s), 0 drug profile(s), and 11 patent record(s) to this entity from public FDA, EMA, ClinicalTrials.gov, and USPTO sources. Pipeline phase mix: phase 2 (6), phase 3 (3), phase 1 (3).

Company snapshot

We are a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined diseases in areas of high unmet medical need, with an initial focus on rare diseases. Community Guidelines: https://bit.ly/3t2xeR9

  • 12 active pipeline program(s) linked via ClinicalTrials.gov.
  • 11 US patent(s) indexed to this assignee profile.
  • 12 trial update(s) in the last 12 months.

Public regulatory, clinical, patent, and corporate records for Fulcrum Therapeutics. Not investment advice.

Catalysts

Upcoming readouts, regulatory dates, and congress activity.

  • trial_data

    New Radiopharmaceutical Shows Promise in Post-Pluvicto Setting, Offering Competitive Insights

  • approval

    Fulcrum Therapeutics Stock Plummets 54% Following Sickle Cell Drug Discontinuation

  • approval

    Ten-Year-Old Cambridge Biotech Seeks Merger or Acquisition Amidst Market Pressures

  • trial_data

    Fulcrum Explores Sale Amid FDA Setback for Sickle Cell Drug

  • trial_data

    FDA Concerns About Cancer Risk Sink Fulcrum Therapeutics’ Sickle Cell Disease Drug: Implications for SCD Pipeline and BD Strategy

  • approval

    Weekly Buzz: PHG, KMDA Win FDA Nod; FULC Halts Pociredir; RMD Closes Noctrix Deal; NVS Paces In IgAN

Recent coverage

Weekly Buzz: PHG, KMDA Win FDA Nod; FULC Halts Pociredir; RMD Closes Noctrix Deal; NVS Paces In IgAN
High impact AnalysisIgANJun 6, 2026

Weekly Buzz: PHG, KMDA Win FDA Nod; FULC Halts Pociredir; RMD Closes Noctrix Deal; NVS Paces In IgAN

FDA · IgAN · 6 min

This week, the biotech sector saw a wave of regulatory and business development activity: PHG and KMDA won FDA approvals, FULC halted its pociredir program, RMD closed the Noctrix acquisition, and NVS posted positive data in IgAN. We break down what each event means for pharma teams and investors.

Dr. Sarah Mitchell
FDA Concerns About Cancer Risk Sink Fulcrum Therapeutics’ Sickle Cell Disease Drug: Implications for SCD Pipeline and BD Strategy
High impact Analysissickle cell diseaseJun 4, 2026

FDA Concerns About Cancer Risk Sink Fulcrum Therapeutics’ Sickle Cell Disease Drug: Implications for SCD Pipeline and BD Strategy

FDA · sickle cell disease · 4 min

Fulcrum Therapeutics is discontinuing its lead sickle cell disease drug, pociredir, after the FDA raised concerns about cancer risk. The decision, which sent shares down 52%, reshapes the SCD competitive landscape and opens strategic questions for pipeline watchers and BD teams.

Dr. Sarah Mitchell
Fulcrum Therapeutics Stock Plummets 54% Following Sickle Cell Drug Discontinuation
High impact Newssickle cell diseaseJun 3, 2026

Fulcrum Therapeutics Stock Plummets 54% Following Sickle Cell Drug Discontinuation

Food and Drug Administration · sickle cell disease · 5 min

Fulcrum Therapeutics' stock experienced a significant 54% drop following the discontinuation of its sickle cell disease drug, citing regulatory hurdles. This event highlights potential challenges in clinical trial design for the indication.

Dr. Sarah Mitchell
Ten-Year-Old Cambridge Biotech Seeks Merger or Acquisition Amidst Market Pressures
High impact Newssickle cellJun 3, 2026

Ten-Year-Old Cambridge Biotech Seeks Merger or Acquisition Amidst Market Pressures

FDA · sickle cell · 6 min

A ten-year-old Cambridge-based biotech company is actively seeking a merger or acquisition. This move comes as public markets have shown volatility, impacting biotech valuations.

Dr. Sarah Mitchell

Lead pipeline drugs

Active clinical programs

Momentum

Proprietary activity score for Fulcrum Therapeutics.

2 active signals

35 /100 +0 vs 30 days ago

Signal breakdown

  • Clinical trials 11 30d
  • Nova articles 6 30d
  • Patents filed 0 30d
  • FDA actions 0 30d
  • SEC filings 0 30d
  • Conference presentations 0 90d
  • Pipeline advances 0 30d

Recent activity

Latest pipeline, patent, and corporate events for Fulcrum Therapeutics.

  1. Clinical update

    1821-FSH-301 — Phase 3

  2. Clinical update

    Pociredir oral capsule(s) — Phase 1

  3. Clinical update

    Losmapimod oral tablet — Phase 2

  4. Clinical update

    Losmapimod oral tablet — Phase 3

  5. Clinical update

    FTX-6058/placebo oral capsule(s) — Phase 1

View all clinical trial activity →

Quick answers

Common questions about this sponsor — for analysts and search.

  • What is Fulcrum Therapeutics?

    Fulcrum Therapeutics is a pharma organization headquartered in Cambridge, USA. It trades on NYSE under ticker FULC. Primary therapeutic focus areas include Facioscapulohumeral Muscular Dystrophy (FSHD), Facioscapulohumeral Muscular Dystrophy 1 (FSHD1), Sickle Cell Disease, Campyl

  • Is Fulcrum Therapeutics publicly traded?

    Yes. Fulcrum Therapeutics is listed with ticker FULC on NYSE per SEC EDGAR records linked on this profile.

  • What drugs does Fulcrum Therapeutics develop or market?

    We link 8 drug profile(s) where Fulcrum Therapeutics is an originator or marketer in FDA or regional approval metadata. See the drug portfolio table on https://novapharmanews.com/companies/fulcrum-therapeutics#company-drugs.

  • What are the latest developments for Fulcrum Therapeutics?

    In the last 12 months our linked public records show 12 trial program update(s) and 0 US patent grant(s) tied to this profile.

  • What therapeutic areas does Fulcrum Therapeutics focus on?

    Fulcrum Therapeutics focuses on Facioscapulohumeral Muscular Dystrophy (FSHD), Facioscapulohumeral Muscular Dystrophy 1 (FSHD1), Sickle Cell Disease based on our analysis of their pipeline programs and drug development activities.

Therapeutic focus

Therapeutic area distribution

Pipeline concentration by therapeutic area from linked clinical programs.

Programs by therapeutic area

Others
16
Infectious Disease
3
Neurology
1