Oncology · Phase III

Top sponsors

• AstraZeneca 75 programs
• Chinese Academy of 70 programs
• HOFFMANN-LA ROCHE 68 programs
• MSD Merck Sharp 56 programs
• First People's Hospital 53 programs
• Ningbo Cancer Hospital 44 programs
• United Therapeutics Europe 43 programs
• Anaxis Pharma 37 programs
• AstraZeneca 37 programs
• Novartis India 32 programs
• George Institute for 29 programs
• Takeda 28 programs

1. DESTINYEndometrial01

   AstraZeneca AB

   HER2-Expressing (IHC 3+/IHC 2+), Mismatch Repair Proficient (pMMR), Primary Advanced or Recurrent Endometrial Cancer

   phase 3 · small molecule · active

   1 trial →

2. DICES

   COLLEGIUM PHARMACEUTICAL, INC

   Breast cancer

   phase 3 · other · active

   1 trial →

3. DLY201619

   Xiyuan Hospital of China Academy of Chinese Medical Sciences

   Non-small Cell Lung Cancer Stage IIIA

   phase 3 · small molecule · terminated

   1 trial →

4. DOCETAXEL

   Pfizer Australia Pty Ltd

   Non-Small Cell Lung Cancer (NSCLC)

   phase 3 · small molecule · active

   1 trial →

5. DS-8201a

   Daiichi Sankyo

   Advanced (unresectable or metastatic) human epidermal growth receptor 2 (HER2)-expressing/HER2-mutated solid tumors

   phase 3 · small molecule · active

   1 trial →

6. DS1062-328

   Daiichi Sankyo

   Locally Advanced or Metastatic Urothelial Carcinoma

   phase 3 · small molecule · active

   1 trial →

7. DS1062-A-U304

   Daiichi Sankyo

   Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

   phase 3 · small molecule · active

   1 trial →

8. DS6000-109

   Daiichi Sankyo

   Platinum-resistant, high-grade serous ovarian cancer (OVC),high-grade endometrioid OVC, primary peritoneal cancer, or fallopian tube cancer

   phase 3 · small molecule · active

   1 trial →

9. DS7300-188

   Daiichi Sankyo

   Small Cell Lung Cancer (SCLC)

   phase 3 · small molecule · active

   1 trial →

10. DS7300-202

    Daiichi Sankyo

    Esophageal Squamous Cell Carcinoma (ESCC)

    phase 3 · small molecule · active

    1 trial →

11. DS8201-724

    Daiichi Sankyo

    Unresectable, Locally Advanced or Metastatic HER2 positive Gastric or Gastroesophageal Junction Cancer

    phase 3 · small molecule · active

    1 trial →

12. DS8201-772

    Daiichi Sankyo

    Ovarian Cancer

    phase 3 · small molecule · active

    1 trial →

13. DS8201-793

    Daiichi Sankyo

    Unresectable or Metastatic HER2 overexpressing and PD-L1 TPS <50% Non-squamous Non-small Cell Lung Cancer

    phase 3 · small molecule · active

    1 trial →

14. DS8201-854

    Daiichi Sankyo

    HER2-expressing endometrial cancer (IHC 3+/2+)

    phase 3 · small molecule · active

    1 trial →

15. DS8201-A-U302

    Daiichi Sankyo

    Metastatic breast cancer

    phase 3 · small molecule · active

    1 trial →

16. DS8201-A-U305

    Daiichi Sankyo

    High-Risk HER2-Positive Breast Cancer

    phase 3 · small molecule · active

    1 trial →

17. DS8201-A-U306

    Daiichi Sankyo

    Metastatic Gastric Adenocarcinoma

    phase 3 · small molecule · active

    1 trial →

18. DUO-O/D081RC00001

    AstraZeneca AB

    Newly diagnosed advanced (FIGO stage III-IV) high grade epithelial ovarian, fallopian or primary peritoneal cancer

    phase 3 · small molecule · active

    1 trial →

19. DZ2024B0002

    Lacuna Pharma Pty Ltd

    Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

    phase 3 · small molecule · active

    1 trial →

20. Dabrafenib

    Novartis Pharmaceuticals

    Malignant Melanoma

    phase 3 · small molecule · completed

    1 trial →

21. Dactinomycin

    Children's Hospital of Fudan University

    Adult Kidney Wilms Tumor

    phase 3 · mab · active

    1 trial →

22. Darbepoetin alfa

    Amgen

    Non-Small Cell Lung Cancer

    phase 3 · small molecule · terminated

    1 trial →

23. Darleukin, Fibromun

    Philogen S.p.A.

    Malignant melanoma of the skin in patients with locally advanced and fully resectable melanoma with/without prior therapy and presence of injectable cutaneous and/or subcutaneous or nodal lesions

    phase 3 · small molecule · active

    1 trial →

24. Darovasertib

    IDEAYA Biosciences

    Uveal Melanoma

    phase 3 · small molecule · active

    2 trials →

25. Dato-DXd

    AstraZeneca

    Breast Cancer

    phase 3 · small molecule · active

    2 trials →

26. Datopotamab deruxtecan for Stage I-III Triple-negative Bre…

    AstraZeneca AB

    Stage I-III Triple-negative Breast Cancer with residual invasive disease after neoadjuvant systemic therapy.

    phase 3 · small molecule · active

    1 trial →

27. Datopotamab deruxtecan, DOCETAXEL

    Daiichi Sankyo

    Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

    phase 3 · small molecule · active

    1 trial →

28. Datopotamab deruxtecan, DOCETAXEL

    AstraZeneca AB

    TROP2 NMR-positive advanced or metastatic non-squamous non-small cell lung cancer without actionable genomic alterations.

    phase 3 · small molecule · active

    1 trial →

29. Decitabine

    The First People's Hospital of Lianyungang

    Acute Myeloid Leukemia, Adult

    phase 3 · small molecule · active

    1 trial →

30. Decitabine

    The First People's Hospital of Lianyungang

    Acute Myeloid Leukemia

    phase 3 · small molecule · active

    1 trial →

31. Decitabine plus HAAG regimen

    The First People's Hospital of Lianyungang

    Acute Myeloid Leukemia

    phase 3 · small molecule · active

    1 trial →

32. Dendritic cell immunotherapy

    NORTHWEST BIOTHERAPEUTICS INC

    Prostate Cancer

    phase 3 · small molecule · terminated

    1 trial →

33. Denosumab

    Amgen

    Cancer

    phase 3 · small molecule · completed

    1 trial →

34. Dinutuximab

    United Therapeutics Europe Ltd

    Small Cell Lung Cancer

    phase 3 · mab · completed

    1 trial →

35. Distress Thermometer and Problems List

    United Therapeutics Europe Ltd

    Cancer

    phase 3 · other · completed

    1 trial →

36. Docetaxel

    AstraZeneca

    Prostate Cancer

    phase 3 · small molecule · completed

    1 trial →

37. Docetaxel

    Sanofi Pasteur

    Non-small Cell Lung Cancer

    phase 3 · small molecule · completed

    1 trial →

38. Docetaxel+lobaplatin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Lobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma

    phase 3 · small molecule · active

    1 trial →

39. Docetaxel, cisplatin and fluorouracil

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Nasopharyngeal Carcinoma

    phase 3 · small molecule · active

    1 trial →

40. Dociparstat

    Jazz Pharmaceuticals Ireland Limited

    Acute Myeloid Leukemia

    phase 3 · small molecule · terminated

    1 trial →

41. Domvanalimab

    Arcus Biosciences

    Advanced Upper Gastrointestinal Tract Adenocarcinoma

    phase 3 · small molecule · active

    1 trial →

42. Dostarlimab

    GlaxoSmithKline

    Neoplasms, Head and Neck

    phase 3 · small molecule · active

    1 trial →

43. Doxorubicin

    Takeda

    Hodgkin Lymphoma

    phase 3 · small molecule · active

    1 trial →

44. Doxorubicine + docetaxel sequential

    Sanofi Pasteur

    Breast Neoplasms

    phase 3 · small molecule · completed

    1 trial →

45. Drug: Ivonescimab Injection

    Summit Therapeutics

    Metastatic Colorectal Cancer (CRC)

    phase 3 · small molecule · active

    1 trial →

46. Durvalumab

    AstraZeneca

    Non Small Cell Lung Cancer NSCLC

    phase 3 · small molecule · active

    1 trial →

47. Durvalumab

    AstraZeneca

    Non-Small Cell Lung Cancer

    phase 3 · small molecule · active

    2 trials →

48. Durvalumab

    AstraZeneca

    Muscle Invasive Bladder Cancer

    phase 3 · small molecule · active

    1 trial →

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