Metabolic & obesity · Phase III

Top sponsors

• Takeda 35 programs
• NovoThirteen 25 programs
• Eli Lilly and 20 programs
• Regeneron UK 12 programs
• Boehringer Ingelheim 10 programs
• Novo Nordisk A/S 10 programs
• AstraZeneca 9 programs
• LEXICON PHARMACEUTICALS 8 programs
• Eli Lilly and 6 programs
• HOFFMANN-LA ROCHE 6 programs
• George Institute for 5 programs
• Kailera Therapeutics 5 programs

1. PTC923, PTC923

   PTC THERAPEUTICS, INC.

   Metabolic Disorders - Phenylketonuria

   phase 3 · small molecule · active

   1 trial →

2. Pioglitazone and Azilsartan

   Takeda

   Type 2 Diabetes

   phase 3 · small molecule · terminated

   1 trial →

3. Pioglitazone and Glimepiride

   Takeda

   Diabetes Mellitus

   phase 3 · small molecule · completed

   1 trial →

4. Pioglitazone-Azilsartan

   Takeda

   Diabetes Mellitus, Type 2

   phase 3 · small molecule · terminated

   1 trial →

5. Placebo

   LEXICON PHARMACEUTICALS, INC.

   Type 2 Diabetes Mellitus

   phase 3 · small molecule · completed

   2 trials →

6. Placebo

   Boehringer Ingelheim

   Diabetes Mellitus, Type 2

   phase 3 · small molecule · completed

   3 trials →

7. Placebo

   LEXICON PHARMACEUTICALS, INC.

   Type 1 Diabetes Mellitus

   phase 3 · small molecule · completed

   2 trials →

8. Placebo

   Takeda

   Diabetes Mellitus, Type 2

   phase 3 · small molecule · completed

   2 trials →

9. Placebo

   Takeda

   Diabetes

   phase 3 · small molecule · terminated

   1 trial →

10. Placebo of BELAPECTIN, BELAPECTIN

    GALECTIN THERAPEUTICS INC

    Esophageal Varices in NASH Cirrhosis

    phase 3 · small molecule · active

    1 trial →

11. Placebo to match LY

    Eli Lilly Co.

    Overweight or Obesity, OSA (Obstructive Sleep Apnea)

    phase 3 · small molecule · active

    1 trial →

12. Prompt aflibercept

    Regeneron UK Limited

    Diabetic Macular Edema

    phase 3 · small molecule · completed

    1 trial →

13. Prompt aflibercept

    Regeneron UK Limited

    Diabetic Retinopathy

    phase 3 · small molecule · completed

    1 trial →

14. REGN4461 - Mibavademab

    Lacuna Pharma Pty Ltd

    Monogenic obesity

    phase 3 · small molecule · active

    1 trial →

15. Resmetirom

    Madrigal Pharmaceuticals EU Limited

    NASH

    phase 3 · small molecule · active

    1 trial →

16. Rimonabant

    Sanofi Pasteur

    Obesity

    phase 3 · small molecule · terminated

    1 trial →

17. S005201-175

    The George Institute

    Type 2 Diabetes inadequately controlled with dapagliflozin with or without metformin

    phase 3 · small molecule · active

    1 trial →

18. SYR-472

    Takeda

    Type 2 Diabetes Mellitus

    phase 3 · small molecule · completed

    1 trial →

19. SYR-472

    Takeda

    Diabetes Mellitus

    phase 3 · small molecule · completed

    5 trials →

20. Saxagliptin

    AstraZeneca

    Diabetes

    phase 3 · small molecule · completed

    1 trial →

21. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Obesity Associated With Defects in Leptin-melanocortin Pathway

    phase 3 · small molecule · active

    2 trials →

22. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Pro-opiomelanocortin (POMC) Deficiency Obesity

    phase 3 · small molecule · completed

    1 trial →

23. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Obesity

    phase 3 · small molecule · active

    1 trial →

24. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Leptin Receptor Deficiency Obesity

    phase 3 · small molecule · completed

    1 trial →

25. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Hypothalamic Obesity

    phase 3 · small molecule · active

    3 trials →

26. Sotagliflozin

    LEXICON PHARMACEUTICALS, INC.

    Type 1 Diabetes Mellitus (T1DM)

    phase 3 · small molecule · completed

    1 trial →

27. Sotagliflozin

    LEXICON PHARMACEUTICALS, INC.

    Type 2 Diabetes Mellitus

    phase 3 · small molecule · terminated

    3 trials →

28. Sotagliflozin

    LEXICON PHARMACEUTICALS, INC.

    Diabetic Nephropathies

    phase 3 · small molecule · active

    1 trial →

29. Sotagliflozin

    LEXICON PHARMACEUTICALS, INC.

    Type 1 Diabetes Mellitus

    phase 3 · small molecule · completed

    3 trials →

30. Sotagliflozin (SAR439954)

    LEXICON PHARMACEUTICALS, INC.

    Type 2 Diabetes Mellitus

    phase 3 · small molecule · completed

    4 trials →

31. Sotagliflozin Low Dose

    LEXICON PHARMACEUTICALS, INC.

    Type 1 Diabetes (T1D)

    phase 3 · small molecule · active

    1 trial →

32. Suspension of autologous mononuclear cells separated from bone marrow aspirate

    The George Institute

    diabetic foot syndrome, lower limb ischemia

    phase 3 · small molecule · active

    1 trial →

33. Suzetrigine

    Vertex Pharmaceuticals (Australia) Pty.

    Diabetic Peripheral Neuropathic Pain

    phase 3 · small molecule · active

    3 trials →

34. TAK-559

    Takeda

    Diabetes Mellitus

    phase 3 · small molecule · terminated

    3 trials →

35. TAK-559 and glyburide

    Takeda

    Diabetes Mellitus

    phase 3 · small molecule · terminated

    1 trial →

36. TAK-559 and insulin

    Takeda

    Diabetes Mellitus

    phase 3 · small molecule · terminated

    1 trial →

37. TAK-559 and metformin

    Takeda

    Diabetes Mellitus

    phase 3 · small molecule · terminated

    1 trial →

38. TAK-875

    Takeda

    Diabetes Mellitus, Type 2

    phase 3 · small molecule · terminated

    4 trials →

39. TAK-875

    Takeda

    Diabetes Mellitus

    phase 3 · small molecule · completed

    3 trials →

40. TAK-875

    Takeda

    Diabetic Patients

    phase 3 · small molecule · completed

    1 trial →

41. TAK-875

    Takeda

    Type 2 Diabetes

    phase 3 · small molecule · terminated

    1 trial →

42. TAK-875

    Takeda

    Type 2 Diabetes Mellitus

    phase 3 · small molecule · terminated

    1 trial →

43. Tang-min Lin pill

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Type 2 Diabetes

    phase 3 · small molecule · active

    1 trial →

44. Teplizumab

    Sanofi Pasteur

    Type 1 Diabetes Mellitus

    phase 3 · small molecule · active

    1 trial →

45. Teplizumab, Matched placebo for test product

    Sanofi-aventis Healthcare Pty Ltd

    Nutritional and metabolic diseases

    phase 3 · small molecule · active

    1 trial →

46. Tesaglitazar

    AstraZeneca

    Type 2 Diabetes

    phase 3 · small molecule · terminated

    1 trial →

47. Tesaglitazar 0.5 or 1 mg

    AstraZeneca

    Type 2 Diabetes

    phase 3 · small molecule · terminated

    1 trial →

48. Tirzepatide

    Eli Lilly and Company

    Metabolic Dysfunction-Associated Steatotic Liver Disease

    phase 3 · small molecule · active

    1 trial →

Frequently asked questions