Infectious disease · Phase III

Top sponsors

• United Therapeutics Europe 22 programs
• GSK Glaxo Smith 20 programs
• BRIGHT MINDS BIOSCIENCES 18 programs
• Chinese Academy of 13 programs
• Takeda 12 programs
• Sinovac Research and 11 programs
• Gilead Sciences Ireland 10 programs
• PARItec 10 programs
• Gilead Sciences 9 programs
• Pfizer 8 programs
• Vir Biotechnology 7 programs
• George Institute for 6 programs

1. Baricitinib

   Eli Lilly Co.

   Covid19 Corona Virus Infection

   phase 3 · small molecule · active

   1 trial →

2. Behavioral Drug and HIV Risk Reduction Counseling

   BRIGHT MINDS BIOSCIENCES INC.

   Opiate Dependence

   phase 3 · other · completed

   1 trial →

3. Bemnifosbuvir (BEM)

   Atea Pharmaceuticals

   Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2 Infection)

   phase 3 · small molecule · completed

   1 trial →

4. Bemnifosbuvir-Ruzasvir

   Atea Pharmaceuticals

   HEPATITIS C VIRUS CHRONIC INFECTION

   phase 3 · small molecule · active

   1 trial →

5. Bemnifosbuvir-Ruzasvir (BEM/RZR)

   Atea Pharmaceuticals

   HEPATITIS C VIRUS CHRONIC INFECTION

   phase 3 · small molecule · active

   1 trial →

6. Bepirovirsen

   GlaxoSmithKline

   Chronic Hepatitis B

   phase 3 · small molecule · completed

   1 trial →

7. Bictegravir

   Gilead Sciences Ireland UC

   HIV-1-infection

   phase 3 · small molecule · active

   2 trials →

8. Brelovitug (BJT-778)

   Mirum Pharmaceuticals International B.V.

   Chronic Hepatitis D

   phase 3 · small molecule · active

   1 trial →

9. Brelovitug 300 mg

   Mirum Pharmaceuticals International B.V.

   Chronic Hepatitis D Infection

   phase 3 · small molecule · active

   3 trials →

10. Brincidofovir

    Jazz Pharmaceuticals Ireland Limited

    Adenovirus Infection

    phase 3 · small molecule · completed

    1 trial →

11. Buprenorphine/Naloxone

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 3 · small molecule · terminated

    1 trial →

12. C4671026

    Pfizer Australia Pty Ltd

    SARS-CoV-2 Infection

    phase 3 · small molecule · active

    1 trial →

13. C5091017

    Pfizer Australia Pty Ltd

    Covid-19 at high risk of progression to severe illness.

    phase 3 · small molecule · active

    1 trial →

14. C5091018

    Pfizer Australia Pty Ltd

    Coronavirus Disease 2019 (COVID-19)

    phase 3 · small molecule · active

    1 trial →

15. CARDIOL 100-03

    Cardiol Therapeutics

    COVID-19

    phase 3 · small molecule · terminated

    1 trial →

16. CAZ-AVI

    Pfizer

    Complicated Intra-Abdominal Infection

    phase 3 · small molecule · completed

    1 trial →

17. CNBG-BIBP-O-2022003

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19

    phase 3 · mab · active

    2 trials →

18. COBI

    Gilead Sciences Ireland UC

    HIV

    phase 3 · small molecule · completed

    1 trial →

19. COVID-19 Vaccine,Inactivated

    Sinovac Research and Development Co.,

    COVID-19

    phase 3 · mab · completed

    1 trial →

20. CP101

    Finch Therapeutics Group

    Recurrent C. Difficile Infection

    phase 3 · mab · terminated

    1 trial →

21. CPI-006 2 mg/kg + SOC

    Corvus Pharmaceuticals

    Covid-19

    phase 3 · small molecule · terminated

    1 trial →

22. CVAY736B2201

    Novartis Pharmaceuticals

    Autoimmune hepatitis

    phase 3 · small molecule · active

    1 trial →

23. Carraguard (PC-515)

    United Therapeutics Europe Ltd

    HIV Infections

    phase 3 · small molecule · completed

    2 trials →

24. Ceftaroline

    Pfizer

    Community-Acquired Bacterial Pneumonia

    phase 3 · small molecule · completed

    1 trial →

25. Ceftazidime - Avibactam ( CAZ-AVI)

    Pfizer

    Complicated Urinary Tract Infection

    phase 3 · small molecule · completed

    1 trial →

26. Ceftazidime-avibactam

    Pfizer

    Complicated Intra-abdominal Infection

    phase 3 · small molecule · completed

    1 trial →

27. Ceftriaxone

    Adaptive Biotechnologies Corp

    Community-acquired Pneumonia, Influenza, COVID-19

    phase 3 · small molecule · active

    1 trial →

28. Cellulose Sulfate gel (6%)

    United Therapeutics Europe Ltd

    HIV Infection

    phase 3 · small molecule · terminated

    1 trial →

29. Cervarix™

    GlaxoSmithKline

    Infections, Papillomavirus

    phase 3 · mab · completed

    1 trial →

30. Cetirizine

    BRIGHT MINDS BIOSCIENCES INC.

    COVID-19

    phase 3 · small molecule · terminated

    1 trial →

31. Cholecalciferol (Vitamin D/Vigantol oil)

    United Therapeutics Europe Ltd

    Respiratory Tract Infections

    phase 3 · other · completed

    1 trial →

32. Clesrovimab

    Merck KGaA, Darmstadt, Germany

    Respiratory Syncytial Virus Infection

    phase 3 · mab · completed

    1 trial →

33. Co-Trimoxazole 960Mg Dispersible Tablet

    United Therapeutics Europe Ltd

    Spontaneous Bacterial Peritonitis

    phase 3 · small molecule · active

    1 trial →

34. D3 (Penta 21)

    Fondazione Telethon ETS

    HIV-infected

    phase 3 · small molecule · active

    1 trial →

35. D7000C00001

    AstraZeneca AB

    COVID-19

    phase 3 · small molecule · active

    1 trial →

36. DEXMEDETOMIDINE , 18F-DPA-714

    Pari Pharma GmbH

    Patients who survive a COVID ARDS in intensive care must be weaned off invasive mechanical ventilation as quickly as possible. 60% of these patients present with intensive care delirium, a serious event that causes excess mortality and potential acute and late complications, since 30% of patients who present with delirium develop cognitive sequelae. Severe neuroinflammation is considered to be one of the main pathophysiological mechanisms causing delirium during ventilatory weaning. In addition to its sedative properties, dexmedetomidine has neuroprotective effects. In certain experimental models, it reduces cerebral inflammation by acting directly on the microglial phenotype. The role of this chronic neuroinflammatory state on cognitive capacity and reserve is beginning to emerge in the literature, regardless of the initial stress (surgery, head injury or Alzheimer's-type dementia), and is therefore capable of influencing patients' quality of life. The assessment of this neuroinflammation using non-invasive tools would appear to be of prime importance in the management of post-COVID neuro injured patients, as well as the evaluation of potential neuroprotective agents such as dexmedetomidine.

    phase 3 · small molecule · active

    1 trial →

37. DOR/ISL

    Merck KGaA, Darmstadt, Germany

    HIV Infection

    phase 3 · small molecule · active

    1 trial →

38. DTG + 3TC

    ViiV Healthcare B.V.

    HIV Infections

    phase 3 · small molecule · completed

    1 trial →

39. DUO2025_01

    Lacuna Pharma Pty Ltd

    Complicated skin wounds (wounds healing per secundam via granulation tissue) - either as a complication of healing of acute wounds (infected surgical or traumatic wounds) or chronic wounds, in both cases infected with S. aureus and/or P. aeruginosa.

    phase 3 · small molecule · active

    1 trial →

40. Daclatasvir

    Bristol-Myers Squibb

    Hepatitis C Virus Infection

    phase 3 · small molecule · completed

    2 trials →

41. Descovy or Truvada

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 3 · small molecule · completed

    1 trial →

42. Directly administered antiretroviral therapy (DAART)

    BRIGHT MINDS BIOSCIENCES INC.

    HIV Infections

    phase 3 · other · completed

    2 trials →

43. Dociparstat sodium

    Jazz Pharmaceuticals Ireland Limited

    Coronavirus Disease 2019 (COVID-19)

    phase 3 · small molecule · terminated

    1 trial →

44. Dolutegravir/abacavir/lamivudine FDC

    ViiV Healthcare B.V.

    Infection, Human Immunodeficiency Virus

    phase 3 · small molecule · completed

    1 trial →

45. Doxy-WISE

    The George Institute

    Sexually Transmitted Infections

    phase 3 · small molecule · active

    1 trial →

46. Drotrecogin alfa (activated)

    Eli Lilly and Company

    Sepsis

    phase 3 · small molecule · completed

    1 trial →

47. Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment

    United Therapeutics Europe Ltd

    COVID19

    phase 3 · small molecule · active

    1 trial →

48. EVO100

    Evofem Biosciences

    Chlamydia Trachomatis Infection

    phase 3 · small molecule · completed

    1 trial →

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