Wednesday, June 10, 2026

Drug profile · INN

metformin

metformin (APO-METFORMIN XR 1000) is a mitochondrial complex i (nadh dehydrogenase) inhibitor. Associated with Alphapharm Pty Ltd.

TGA: approved NMPA: clinical trials
Patents linked 4
Pipeline programs 68
News articles 1
Drug details — metformin

Quick answer

metformin (APO-METFORMIN XR 1000) is a mitochondrial complex i (nadh dehydrogenase) inhibitor. Associated with Alphapharm Pty Ltd.

Key facts

INN metformin
Brand APO-METFORMIN XR 1000
Mechanism Mitochondrial complex I (NADH dehydrogenase) inhibitor

Mechanism of action

Mitochondrial complex I (NADH dehydrogenase) inhibitor

Approval history

Authority Status Date
TGA approved
NMPA clinical trials

Recent coverage

Pipeline programs

  1. ANDA219975 + ANDA220011 Phase 3 · Lxo Ireland Designated · Type 2 Diabetes
  2. APHP220832 Phase 3 · PARItec · Myotonic dystrophy type 1 (DM1)
  3. Alogliptin and metformin Phase 3 · Takeda · Diabetes Mellitus
  4. Alogliptin and metformin Phase 3 · Takeda · Type 2 Diabetes Mellitus
  5. CAPECITABINE for Locally advanced stage II/III rectal cancer Phase 3 · Telethon Foundation · Locally advanced stage II/III rectal cancer
  6. CT-L03-301 Phase 3 · Celltrion Healthcare Australia · Type 2 diabetes mellitus (T2DM)
  7. D20180102 Phase 3 · PARItec · Vascular calcification and type 1 diabetes
  8. J2A-MC-GZGW Phase 3 · Eli Lilly and · Type 2 Diabetes
  1. US 10363244

    Compositions comprising metformin and a glucokinase activator

    Expires Mon Jul 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10064846

    Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator

    Expires Mon Aug 30 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 9855251

    Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator

    Expires Mon Dec 28 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 9359313

    Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator

    Expires Mon Jun 02 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is metformin?

metformin (APO-METFORMIN XR 1000) is a mitochondrial complex i (nadh dehydrogenase) inhibitor. Associated with Alphapharm Pty Ltd.

What is the brand name for metformin?

APO-METFORMIN XR 1000 is a marketed brand name for metformin. Check FDA Drugs@FDA for the current US label holder and prescribing information.