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Intelligence · Clinical Pipeline

Autoimmune & immunology R&D Pipeline

Autoimmune, rheumatology, and immunology biologics in clinical development.

Programs
987

Quick answer

Autoimmune & immunology: NovaPharmaNews indexes 987 autoimmune & immunology clinical pipeline programs from ClinicalTrials.gov with phase, modality, NCT identifiers, and sponsor company links. Autoimmune, rheumatology, and immunology biologics in clinical development.

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  1. Sonelokimab

    MoonLake Immunotherapeutics

    axial spondyloarthritis

    phase 2 small molecule active

    1 trial

  2. Spesolimab

    Boehringer Ingelheim

    Generalized Pustular Psoriasis

    phase 2 small molecule active

    1 trial

  3. Splinting

    United Therapeutics Europe Ltd

    Hand Osteoarthritis

    phase 2 other completed

    1 trial

  4. Stem cells

    Takeda

    Rheumatoid Arthritis Aggravated

    phase 2 gene therapy completed

    1 trial

  5. Stromal-vascular fraction

    Century Therapeutics

    Knee Osteoarthritis

    phase 2 mab active

    1 trial

  6. Study evaluating the efficacy of the treatment after targeting PD-L1 and TIGIT in tumors with tertiary lymphoid structures

    The George Institute

    Adult patients with a histologically confirmed TLS-positive advanced or metastatic NSCLC naïve from systemic treatment or previously treated with chemotherapy and PD1/PDL1 antagonist, and not having previously been treated with CD137 agonists or investigational immune checkpoint blockade therapies, including (but not limited) anti-TIGIT, anti-LAG3. Patients must have adequate organ function with a performance status (WHO 0-1; ECOG 0-1). Patients must not have active or history of autoimmune disease or immune deficiency. The pregnant or breastfeeding women will be excluded. Other eligibility criteria are described in the related section of the protocol.

    phase 2 other active

    1 trial

  7. TAK-018

    Takeda

    Crohn Disease

    phase 2 small molecule terminated

    1 trial

  8. TAK-079

    Takeda

    Myasthenia Gravis

    phase 2 small molecule completed

    1 trial

  9. TAK-279

    Takeda

    Ulcerative Colitis

    phase 2 small molecule active

    1 trial

  10. TAK-279

    Takeda

    Crohn's Disease

    phase 2 small molecule active

    1 trial

  11. TAK-279 Placebo (same excipient as TAK-279), ZASOCITINIB

    Takeda

    Moderate to Severely Active Ulcerative Colitis

    phase 2 small molecule active

    1 trial

  12. TAK-279 placebo (same excipient as TAK-279), ZASOCITINIB, ZASOCITINIB

    Takeda

    Moderately to Severely Active Crohn's Disease

    phase 2 small molecule active

    1 trial

  13. TAK-715 and methotrexate

    Takeda

    Arthritis, Rheumatoid

    phase 2 small molecule completed

    1 trial

  14. TAK-783 and methotrexate

    Takeda

    Arthritis, Rheumatoid

    phase 2 small molecule completed

    1 trial

  15. TEV-48574

    Lacuna Pharma Pty Ltd

    Crohn’s disease, Ulcerative colitis

    phase 2 small molecule active

    1 trial

  16. TEV-48574

    Teva Pharma GmbH

    Crohn Disease

    phase 2 small molecule completed

    1 trial

  17. TEV-48574 Dose Regimen A

    Teva Pharma GmbH

    Crohn Disease

    phase 2 small molecule active

    1 trial

  18. TEV-48574, Placebo IMP for sc infusion is provided as a liquid solution in the same formulation as TEV-48574, except for the absence of active protein.

    Lacuna Pharma Pty Ltd

    Crohn’s disease, Ulcerative colitis

    phase 2 small molecule active

    1 trial

  19. TOCILIZUMAB , CYCLOPHOSPHAMIDE , CD19-CAR_Lenti, FLUDARABINE , LEVETIRACETAM

    Fondazione Telethon ETS

    Refractory Systemic Autoimmune Diseases

    phase 2 small molecule active

    1 trial

  20. TV-45070

    Teva Pharma GmbH

    Osteoarthritis of the Knee

    phase 2 small molecule completed

    1 trial

  21. Taodan Granules

    Universal Integrated

    Psoriasis Vulgaris

    phase 2 small molecule active

    1 trial

  22. Teduglutide (ALX-0600)

    Takeda

    Crohn's Disease

    phase 2 small molecule completed

    1 trial

  23. Telitacicept

    The First People's Hospital of Lianyungang

    Systemic Lupus Erythematosus

    phase 2 small molecule active

    1 trial

  24. Telotristat Etiprate

    LEXICON PHARMACEUTICALS, INC.

    Ulcerative Colitis

    phase 2 small molecule completed

    1 trial

  25. Tocilizumab Injectable Product

    Tang-Du Hospital

    Myasthenia Gravis, Generalized

    phase 2 small molecule active

    1 trial

  26. Topical Rose Bengal, 0.005%

    PROVECTUS BIOPHARMACEUTICALS, INC.

    Psoriasis

    phase 2 small molecule completed

    1 trial

  27. Triamcinolone Acetonide Acetate and Urea Cream.

    Universal Integrated

    Psoriasis Vulgaris

    phase 2 small molecule active

    1 trial

  28. Tyenne 162 mg solution for injection in pre-filled pen

    Cardiff Oncology

    Psoriatic Arthritis, Rheumatoid Arthritis

    phase 2 small molecule active

    1 trial

  29. Tyenne 162 mg solution for injection in pre-filled pen

    Cardiff Oncology

    Psoriatic Arthritis, Rheumatoid Arthritis

    phase 2 small molecule active

    1 trial

  30. Ublituximab

    TG THERAPEUTICS, INC.

    Autoimmune Disorders

    phase 2 small molecule active

    1 trial

  31. Ultomiris 300 mg/30 mL concentrate for solution for infusion, Concentrate for solution for infusion

    Alexion Europe SAS

    Lupus Nephritis (LN) Immunoglobulin A Nephropathy (IgAN)

    phase 2 small molecule active

    1 trial

  32. Upadacitinib, Upadacitinib

    AbbVie Deutschland GmbH & Co. KG

    Crohn's Disease (CD)

    phase 2 small molecule active

    1 trial

  33. Uplizna 100 mg concentrate for solution for infusion

    Amgen

    Generalized Myasthenia Gravis

    phase 2 small molecule active

    1 trial

  34. Use autologous cSVF + MSCs (cryo) for management of autoimmune component, anti-inflammatory and immune modulation

    Blackmores Limited

    Autism Spectrum Disorder

    phase 2 mab active

    1 trial

  35. VAY736, TENOFOVIR ALAFENAMIDE, ENTECAVIR , -, VAY736, VAY736, TENOFOVIR DISOPROXIL

    Novartis Pharmaceuticals

    Rheumatoid Arthritis, Sjögren’s Disease, Systemic Lupus erythematosus

    phase 2 small molecule active

    1 trial

  36. VX-150

    Vertex Pharmaceuticals (Australia) Pty.

    Osteoarthritis

    phase 2 small molecule completed

    1 trial

  37. VX-702

    Vertex Pharmaceuticals (Australia) Pty.

    Rheumatoid Arthritis

    phase 2 small molecule completed

    2 trials

  38. VX-765

    Vertex Pharmaceuticals (Australia) Pty.

    Psoriasis

    phase 2 small molecule completed

    1 trial

  39. Vancomycin Pre-Treatment

    Seres Therapeutics

    Ulcerative Colitis

    phase 2 small molecule terminated

    1 trial

  40. Vedolizumab 300 MG Injection [Entyvio]

    Takeda

    Immune Checkpoint Inhibitor-Related Colitis

    phase 2 small molecule active

    1 trial

  41. Vedolizumab intravenous injection

    Takeda

    Ulcerative Colitis

    phase 2 small molecule terminated

    1 trial

  42. Veltuzumab

    Takeda

    Rheumatoid Arthritis

    phase 2 small molecule terminated

    1 trial

  43. Voclosporin High Dose

    Aurinia Pharmaceuticals

    Lupus Nephritis

    phase 2 small molecule completed

    1 trial

  44. Xanthohumol

    NORTHWEST BIOTHERAPEUTICS INC

    Crohn Disease

    phase 2 small molecule active

    1 trial

  45. YTB323, Flebogamma DIF 50 mg/ml solution for infusion, TOCILIZUMAB, FLUDARABINE PHOSPHATE, CYCLOPHOSPHAMIDE

    Novartis Pharmaceuticals

    Treatment-resistant generalized Myasthenia Gravis

    phase 2 small molecule active

    1 trial

  46. ZASOCITINIB

    Takeda

    Moderate to Severely Active Ulcerative Colitis & Moderate to Severely Active Crohn's Disease

    phase 2 small molecule active

    1 trial

  47. ZL-1102 1% w/w gel BID for 16 weeks

    Hong Kong Baptist University

    Plaque Psoriasis

    phase 2 small molecule active

    1 trial

  48. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Refractory/Relapsed Autoimmune Hemolytic Anemia

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many autoimmune & immunology pipeline programs are tracked?

987 programs match this therapeutic area based on indication text, program name, and registry metadata.

Where does pipeline data come from?

ClinicalTrials.gov records linked to NovaPharmaNews company profiles. Verify on ClinicalTrials.gov before investment decisions.

Data attribution: Data sources · All pipeline programs

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