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Modified Nucleic Acid & Custom mRNA Experts

TriLink BioTechnologies: mRNA & Oligo CDMO

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Overview

TriLink BioTechnologies, part of Maravai LifeSciences, is a leading CDMO specializing in nucleic acid synthesis, including mRNA, oligonucleotides, plasmids, NTPs, and mRNA capping analogs like proprietary CleanCap® technology. They provide scalable manufacturing from research-grade (RUO) to full cGMP for therapeutic, vaccine, and diagnostic applications, with expertise in process development, scale-up, and technology transfer. Operating from a 118,000 sq. ft. facility in San Diego's Sorrento Valley, TriLink supports biopharma from early research to commercial production.

Frequently asked questions

What manufacturing capabilities does TriLink offer for mRNA and oligonucleotides?
TriLink provides a full range of manufacturing from research-grade (RUO) to customizable intermediate-grade GMPLinkTM and full GMP-grade, including cGMP mRNA, oligonucleotide, and plasmid production with scale-up and technology transfer expertise at their San Diego facility.
What is TriLink's CleanCap® technology and its benefits?
CleanCap® is a proprietary co-transcriptional mRNA capping reagent that simplifies manufacturing by eliminating enzymatic steps, delivering high capping efficiency, improved yields, and supporting over 350 clinical programs and 3 approved vaccines.
Where are TriLink's facilities located and what do they support?
TriLink operates a custom-built 118,000 sq. ft. facility in San Diego's Sorrento Valley with over 50,000 sq. ft. of manufacturing space, supporting process development, oligonucleotide synthesis, custom mRNA synthesis, cGMP manufacturing, analytical services, and in vivo gene editing.