Overview
DNA Script is a biotechnology company specializing in enzymatic DNA synthesis technology, offering the SYNTAX benchtop DNA printer for on-demand, same-day synthesis of custom oligonucleotides. Their platform enables researchers to produce high-quality single-stranded DNA oligos in-house with automated synthesis, desalting, quantification, and normalization capabilities. The SYNTAX system synthesizes up to 96 oligos in parallel and supports modifications including fluorescent tags, with expanded capabilities for RNA synthesis and gene assembly in development.
Frequently asked questions
- What is the SYNTAX DNA printer and what can it produce?
- The SYNTAX is a fully integrated benchtop instrument that enables template-free enzymatic synthesis of up to 96 oligonucleotides in parallel. It synthesizes, desalts, quantifies, and normalizes oligos with or without fluorescent or other modifications, delivering same-day results directly at the researcher's bench.
- How does DNA Script's enzymatic DNA synthesis differ from traditional chemical methods?
- DNA Script uses highly engineered Terminal Deoxynucleotidyl Transferase (TdT) enzymes that add reversibly-terminated nucleotides with high fidelity and coupling efficiency. This enzymatic approach has surpassed legacy chemical synthesis methods in both capability and efficiency, enabling production of longer oligos and more sustainable manufacturing.
- What are the primary applications for the SYNTAX system?
- Applications include site-directed mutagenesis, targeted cancer panels, and 16S metagenomic sequencing. The platform also supports custom oligo synthesis up to 500 nucleotides through DNA Script's services, with future capabilities planned for RNA synthesis and automated gene assembly.
- What is the turnaround time for DNA synthesis with SYNTAX?
- The SYNTAX system enables same-day synthesis of custom oligos, allowing researchers to print DNA on demand directly at their bench within hours, providing immediate access to synthetic DNA without external dependencies.
- Does DNA Script offer custom synthesis services beyond the benchtop printer?
- Yes, DNA Script provides custom synthesis services for complex oligonucleotides up to 500 nucleotides in length, complementing the in-house SYNTAX printer capabilities for researchers requiring longer or more specialized sequences.