Overview
Nautilus Biotechnology pioneers single-molecule proteome analysis through its Voyager Platform, designed to measure up to 10 billion intact proteins and proteoforms simultaneously in a single run. The platform delivers accurate quantification with unprecedented dynamic range across the entire proteome, enabling pharmaceutical and research organizations to generate deep biological insights for drug discovery, biomarker identification, and disease research. Using proprietary Iterative Mapping technology and machine-learning powered analysis, the benchtop instrument requires no special lab facilities and provides reproducible, digital protein counts suitable for AI workflows.
Frequently asked questions
- What is the Nautilus Voyager Platform and how does it work?
- The Voyager Platform uses Iterative Mapping to enable single-molecule quantification of up to 10 billion intact proteins and proteoforms simultaneously in a single run. It employs DNA scaffolds and proprietary protein library preparation techniques to achieve super-Poisson loading, delivering measurements across an unprecedented dynamic range of up to 9 orders of magnitude with high accuracy and reproducibility.
- What are the key capabilities and specifications?
- The platform can detect molecular entities at concentrations as low as 1,000 parts per million, measure proteins in yoctomole quantities, and maintain linear quantification across greater than 3 orders of magnitude. It features machine-learning powered analysis, a user-friendly touchscreen interface, and benchtop design requiring no special lab facility requirements.
- What validation and field experience does Nautilus have?
- Nautilus successfully installed and tested its first external field evaluation unit at the Buck Institute for Research on Aging, where researchers generated highly reproducible data from neurodegenerative disease samples over more than 6 months. The Voyager Platform was unveiled at the US HUPO 2026 conference, demonstrating its capability for next-generation proteomics across multiple research fields.
- Is the data suitable for downstream analysis and AI applications?
- Yes. Nautilus data is designed to provide direct and detailed measurements of single protein molecules well-suited for AI workflows. The platform produces highly nuanced data capturing proteome diversity with empirical evidence demonstrating linear quantification and detection of low-abundance species, supporting rapid generation of deep biological insights.
- What is the target market and application areas?
- The platform is designed for pharmaceutical R&D, biomarker discovery, neurodegenerative disease research, and broad proteome analysis across any field of research. Nautilus aims to democratize access to proteomics by providing accessible, reproducible single-molecule protein analysis on an integrated benchtop platform.