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Patents

Browse 222 pharma-relevant US patents (A61K/A61P) linked to tracked companies. Patent cliff and LOE intelligence for BD teams.

29,054 patents indexed
patent

US 12410430

Modulating apolipoprotein (A) expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Sep 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Sep 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12410225

Modulation of dendritic cell lineages

Orionis Biosciences, Inc Β· Granted Tue Sep 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Sep 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12409188

Modulators of HSD17B13 expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Sep 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Sep 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12364753

CD8 binding agents

Orionis Biosciences, Inc Β· Granted Tue Jul 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12350285

Compounds and methods for reducing ATXN3 expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Jul 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jul 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12351633

PD-1 and PD-L1 binding agents

Orionis Biosciences, Inc Β· Granted Tue Jul 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jul 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12351614

CLEC9A-based chimeric protein complexes

Orionis Biosciences, Inc Β· Granted Tue Jul 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jul 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12343357

Compositions and methods for modulating MECP2 expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Jul 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jun 26 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12297431

Modulation of huntingtin expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12291709

Compositions and methods for modulating apolipoprotein (a) expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12281305

Compounds and methods for reducing prion expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12275940

Conjugated antisense compounds and their use

Ionis Pharmaceuticals, Inc. Β· Granted Tue Apr 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Apr 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12241067

Compounds and methods for reducing LRRK2 expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12227746

Compounds and methods for modulating SCN2A

Ionis Pharmaceuticals, Inc. Β· Granted Tue Feb 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Feb 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12215321

Modulators of diacyglycerol acyltransferase 2 (DGAT2)

Ionis Pharmaceuticals, Inc. Β· Granted Tue Feb 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jan 30 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12188020

Methods for reducing Ataxin-2 expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12180479

Compounds and methods for modulating ATXN1

Ionis Pharmaceuticals, Inc. Β· Granted Tue Dec 31 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Dec 26 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12152244

Selective antisense compounds and uses thereof

Ionis Pharmaceuticals, Inc. Β· Granted Tue Nov 26 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Nov 21 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12115225

GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof

Ionis Pharmaceuticals, Inc. Β· Granted Tue Oct 15 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Oct 10 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12110491

Selective reduction of allelic variants

Ionis Pharmaceuticals, Inc. Β· Granted Tue Oct 08 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Oct 03 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12091463

Clec9A binding agents comprising a recombinant heavy-chain only antibody (VHH)

Orionis Biosciences, Inc Β· Granted Tue Sep 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Sep 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12084497

SIRP1Ξ± targeted chimeric proteins and uses thereof

Orionis Biosciences, Inc Β· Granted Tue Sep 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Sep 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12043831

Modulation of alpha synuclein expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Jul 23 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jul 18 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted
patent

US 12042510

Modulators of IRF4 expression

Ionis Pharmaceuticals, Inc. Β· Granted Tue Jul 23 2024 00:00:00 GMT+0000 (Coordinated Universal Time) Β· Expires Mon Jul 18 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

granted